Results 71 to 80 of about 734,272 (347)

Modelling of Rocking and Sliding Effects in the Seismic Analysis of a Free-Standing Column

Latin American Journal of Solids and Structures
A study on the seismic response of a free-standing marble column, including rocking and sliding effects, is presented in this paper. The rocking-sliding model implemented for the development of the analyses corresponds to the basic theoretical and ...
S. Sorace, G. Terenzi, C. Bitossi, E. Mori   +3 more
doaj   +1 more source

Rock the Rock of Atherosclerosis [PDF]

Journal of Vascular Medicine & Surgery, 2013
The Rho-Associated Coiled-Coil Containing Protein Kinase (ROCK1 and ROCK2) were one of the downstream effectors of the small GTPase Rho. The Rho/ROCK pathway plays an important role in mediating multiple cellular processes, including endothelial dysfunction, the proliferation and migration of smooth muscle cells, foam cell formation, and arterial ...
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Seismic Performance Criteria for the Rocking and Overturning Behavior of Freestanding Contents in Buildings

Buildings
During a severe earthquake, the violent shaking causes freestanding non-structural elements to sway and overturn, potentially injuring occupants or causing the elements themselves to break apart.
Khine Kyaw, Sung-Hyun Jang, Vikas Mehta, Min-Ho Chey   +3 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

A Practical Noise2Noise Denoising Pipeline for High‐Throughput Raman Spectroscopy

Advanced Engineering Materials, EarlyView.
A lightweight and reproducible denoising pipeline for high‐throughput Raman spectroscopy is introduced, based on a 1D convolutional autoencoder trained with a Noise2Noise strategy. Using only repeated short‐exposure acquisitions, the method suppresses stochastic noise without reference spectra, enabling reliable spectral reconstruction while preserving
David Martin‐Calle, Cesar Alvarez‐Llamas, Vincent Motto‐Ros, Christophe Dujardin, Jérémie Margueritat, David Rodney   +5 more
wiley   +1 more source

Symptom reduction in mal de débarquement syndrome with attenuation of the velocity storage contribution in the central vestibular pathways

Frontiers in Rehabilitation Sciences
BackgroundThe velocity storage mechanism of the central vestibular system is closely associated with the vestibulo-ocular reflex (VOR), but also contributes to the sense of orientation in space and the perception of self-motion.
Jun Maruta, Jun Maruta, Catherine Cho, Catherine Cho, Theodore Raphan, Theodore Raphan, Sergei B. Yakushin   +6 more
doaj   +1 more source

Rocking vibration with friction

Nihon Kikai Gakkai ronbunshu, 2016
The rocking vibration with friction is focused in this study. The fall down conditions of the rocking system with friction are clarified. Rocking vibration is the rotational motion around the both ends of the structure and occurs when the structure is ...
Yuya YASUDA, Tetsuya WATANABE, Akinori TOMODA   +2 more
doaj   +1 more source

Engineering analysis of strong ground rocking and its effect on tall structures

Soil Dynamics and Earthquake Engineering, 2019
Two, the most intensive 6-dof ground motion records were selected from a database of a program of acquiring seismic aftershocks at Kefalonia Greek Island as reported by Perron et al. in 2018 [1] . The maximum Modified Mercalli (MM) intensity VII and peak
P. Bońkowski, Z. Zembaty, M. Minch
semanticscholar   +1 more source