Results 51 to 60 of about 373,953 (291)

Effect of Freezing-Thawing Cycles on the Elastic Waves’ Properties of Rocks

open access: yesGeosciences, 2022
Freezing thawing cycles are known to play an important role in fracture propagation on rock mass and thus in rock slope instabilities. In laboratories, this phenomenon can be studied through the measurement of the velocities of elastic waves. Seven types
Muriel Gasc-Barbier   +1 more
doaj   +1 more source

Rock's pill that rocked the world

open access: yesSouth African Medical Journal, 2010
I was a rookie doctor on the goldmines in the early 1960s. Part of my duties was to look after the families in the villages of the Anglo American mines at Welkom in the Free State. Their invariably large numbers of children prompted me to enquire whether they wished to have assistance in family planning.
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Effect of petrographic composition and chemistry of aggregate on the local and general fracture response of cementitious composites

open access: yesFracture and Structural Integrity, 2022
This paper concerns the results of research into the influence of the composition of rock inclusions on the fracture response of cement-based composite specimens.
M. Vyhl�dal   +8 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Enhanced Interactive Rendering for Rovers of Lunar Polar Region and Martian Surface

open access: yesRemote Sensing
Appropriate environmental sensing methods and visualization representations are crucial foundations for the in situ exploration of planets. In this paper, we developed specialized visualization methods to facilitate the rover’s interaction and decision ...
Jiehao Bi, Ang Jin, Chi Chen, Shen Ying
doaj   +1 more source

Spectrophotometric determination of Pd(Ii) with P-Dimethylaminebenzylidenerhodanine

open access: yesBrazilian Archives of Biology and Technology, 1999
p-Dimethylaminebenzylidenerhodanine in methyl isobutyl ketone was employed as selective and sensitive reagent for the extraction and determination of palladium(II) in metal alloys and rocks.
Lucia Felicidade Dias, Jorge Nozaki
doaj   +1 more source

Use of rock crushing technological wastes for cement concrete compositions

open access: yesВестник СибАДИ, 2022
Introduction. the article deals with the issues of the use of technological waste generated during rocks crushing.Materials and Methods. In the research the rock crushing screenings from the Rezhevsky crushed rock plant and dolomite screenings from the ...
E. N. Khafizova   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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