Results 121 to 130 of about 2,472,145 (237)

Must Longtermists Wish Us All Dead? A Quadrilemma

Journal of Applied Philosophy, EarlyView.
ABSTRACT Longtermists assign great moral importance to making the long‐term future as good as possible, especially by ensuring the survival of humanity. We argue, to the contrary, that on assumptions that are plausible, conservative, or shared by leading longtermists, human extinction will likely augment total utility among human and non‐human animals ...
Nir Eyal, Bastian Steuwer, Shai Meiri
wiley   +1 more source

Multiple positive antibody combinations to rodent-borne pathogens.

, 2019
Multiple positive antibody combinations to rodent-borne pathogens.
Elisabeth Fichet-Calvet (218214), William K. Ampofo (447674), Andrew G. Letizia (6631325), Shirley C. Nimo-Paintsil (6631322), Randal J. Schoepp (628043), Joseph H. K. Bonney (6631328), Benny Borremans (3170499), Kwasi Obiri-Danso (5229659), Emad Mohareb (433314), Karl C. Kronmann (317416)   +9 more
core   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Chronological change in the incidence risk levels of mosquito-borne and rodent-borne infections

International Journal of Infectious Diseases
Introduction: We examined the change over time in the incidence risk levels of mosquito-borne and rodent-borne infections. Methods: We used the data of “Summary of risk assessment of vector-borne disease at Japanese Quarantine ports and airports ...
Dr Soichi Takeishi, Dr Tatsuo Inoue, Dr Koichi Miyamura   +2 more
doaj   +1 more source

Tickborne diseases of the United States : a reference manual for health care providers. Fifth edition, 2018 [PDF]

Based on \u201cTickborne Diseases in Massachusetts: A Physician\u2019s Reference Manual,\u201d produced by collaboration between MDPH, Nancy Shadick, MD, MPH, andNancy Maher, MPH of the RBB Arthritis and Musculoskeletal Diseases Clinical Research Center ...

core  

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source