Results 181 to 190 of about 2,472,145 (237)

Methyl 4‐O‐Demethylbarbatate Destabilises HIF‐1α and Enhances Temozolomide Sensitivity in Glioma Cells

Cell Proliferation, EarlyView.
The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou, Mücahit Varlı, Rundong Liu, Jieun Yu, Hyung‐Ho Ha, Jae‐Seoun Hur, Sang Kyum Kim, Hahyun Park, Hangun Kim   +8 more
wiley   +1 more source

Hantavirus preparedness at human-rodent interfaces: lessons from China's HFRS control and Andes virus transmission in mobile populations. [PDF]

Emerg Microbes Infect
Wang X, Zhang W.
europepmc   +1 more source

A DPP6‐Targeted PET Tracer for Non‐Invasive Imaging of Transplanted Human Islets

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Dipeptidyl peptidase‐like protein 6 (DPP6) is a potential molecular imaging biomarker for pancreatic and transplanted islets of Langerhans. 4hD29 is a single‐domain antibody with nanomolar affinity for DPP6. Here, we demonstrate the generation and validation of [68Ga]Ga‐NOTA‐4hD29 for Positron Emission Tomography (PET) imaging of ...
Amina Khalil, Arturo Roca‐Rivada, Svitlana Vasylovska, Lorenzo J. I. Balestri, Irina Velikyan, Sayro Jawurek, Alexandra C. Title, Burcak Yesildag, Luke R. Odell, Joey Lau, Decio L. Eizirik, Olof Eriksson   +11 more
wiley   +1 more source

Spotted fever <i>Rickettsia</i> and relapsing fever <i>Borrelia</i> in rodents from southern India. [PDF]

Microbiol Spectr
Ansil BR, Pawar T, Majee P, Kapila R, Libang T, Ramakrishnan U.   +5 more
europepmc   +1 more source

Why we Should Study Solitary Species to Understand the Costs of Group‐Living

Ethology, EarlyView.
It's easier to measure the benefits than the costs of a trait. Solitary species benefit by avoiding the costs of group living. Thus, measuring benefits of solitary living informs us about the costs of group living. ABSTRACT While for decades behavioral ecologists have studied the benefits of group living, measuring its costs has been more difficult. It
Lindelani Makuya, Carsten Schradin
wiley   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Updated S2k hidradenitis suppurativa (HS) guidelines provide expert consensus on diagnosis, assessment and comorbidities. Expanded substantially since the 2015 version, they reflect rapid growth in HS literature and aim to improve generalist‐level patient care through evidence‐informed, consensus‐based guidance.
G. B. E. Jemec, B. Villumsen, K. R. van Straalen, H. H. van der Zee, S. Valiukevičienė, T. Tzellos, J. C. Szepietowski, A. Szegedi, D. M. L. Saunte, M. Romanelli, H. Raynal, F. Prignano, E. P. Prens, M. Podda, A. Nassif, A. Molina‐Leyva, Ł. Matusiak, A. V. Marzano, B. M. McGrath, A. I. Liakou, B. Kirby, L. Kemény, E. Just, D. Ioannidis, J. R. Ingram, R. E. Hunger, B. Horváth, P. Guillem, Ø. Grimstad, E. J. Giamarellos‐Bourboulis, M. Dolenc‐Voljč, V. Del Marmol, Z. Bukvić Mokos, V. Bettoli, F. Benhadou, F. G. Bechara, C. C. Zouboulis   +36 more
wiley   +1 more source

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Immune proteomic associations with indices of cortical development in 5‐year‐old children

Journal of Anatomy, EarlyView.
Typically developing 5‐year‐old children (n = 101–126) from the FinnBrain Birth Cohort Study, Finland, underwent both targeted serum immune proteomics and magnetic resonance brain imaging. Multiple inflammatory markers, from one cluster of co‐expressed immune proteins, were negatively associated with indices of cortical development, including thickness,
Aaron Barron, Aylin Rosberg, Jetro J. Tuulari, Minna Lukkarinen, Harri Merisaari, Eero Silver, Venla Kumpulainen, Anni Copeland, Ekaterina Saukko, Alex M. Dickens, Matej Oresic, Tuulia Hyötylainen, Linnea Karlsson, Hasse Karlsson, Isabella L. C. Mariani Wigley, Elmo P. Pulli   +15 more
wiley   +1 more source

Neuroanatomy education through the years: Revisiting the teaching slides used by Sir Wilfrid Edward Le Gros Clark

Journal of Anatomy, EarlyView.
This paper examines the life and legacy of British anatomist Sir Wilfrid Le Gros Clark through his neuroanatomical teaching collection at the University of Oxford. The authors catalogued 103 specimens and analyzed selected slides—including cases of multiple sclerosis, amyotrophic lateral sclerosis, tabes dorsalis, syringomyelia, and the pineal gland's ...
Shiva A. Nischal, Kush M. Kale, Katherine Tourigny, Mohammed Abuelem, Gretchen Greene, Rachel Walsh, Zoltán Molnár   +6 more
wiley   +1 more source