Results 281 to 290 of about 695,363 (337)

An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance

open access: yesAdvanced Science, EarlyView.
This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue   +9 more
wiley   +1 more source

Characterizing the Soil Microbial Community Associated with the Fungal Pathogen <i>Coccidioides immitis</i>. [PDF]

open access: yesJ Fungi (Basel)
Radosevich M   +7 more
europepmc   +1 more source

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species

open access: yesAdvanced Science, EarlyView.
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is the key driver of ferroptosis. The authors discovered that PHOSPHO1 lowers the level of PE in retinal pigment epithelial cells thus reducing the formation of lipid peroxides. Lowering PE levels can also prevent the creation of autolysosomes, reduce the production of free iron ...
Zhiyang Chen   +19 more
wiley   +1 more source

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

open access: yesAdvanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang   +13 more
wiley   +1 more source

Paramyxo- and coronavirus diversity and host associations in non-volant small mammals: evidence of viral sharing. [PDF]

open access: yesVirus Evol
Mortlock M   +7 more
europepmc   +1 more source

Memristive In‐Memory Object Detection with 128 Mb C‐Doped Ge2Sb2Te5 PCM Chip

open access: yesAdvanced Science, EarlyView.
A memristive in‐memory object detection system is presented for edge computing based on a 128 Mb phase change memory chip (40 nm, 99.99999 % yield) enabling in‐memory vector‐matrix multiplication and max computation. A novel mixed‐precision weight mapping reduces analog‐to‐digital‐converter energy by 22.3×.
Chenchen Xie   +13 more
wiley   +1 more source

Metabolic Programming Drives Protective and Inflammatory Monocyte Fates in Viral Encephalitis

open access: yesAdvanced Science, EarlyView.
Bone marrow monocytes infiltrate the West Nile virus‐infected brain and differentiate into HIF1‐α⁺ monocyte‐derived cells (MCs) that diverge into protective, antigen‐presenting or inflammatory, iNOS⁺ MCs with distinct metabolic programs and functions.
Claire L. Wishart   +4 more
wiley   +1 more source

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