Results 311 to 320 of about 942,431 (379)

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Urbanization influences hemorrhagic fever with renal syndrome transmission: 34-year evidence from China's national surveillance. [PDF]

Infect Dis Model
He J, Wang Y, Xu X, Christakos G, Zhang D, Xu Y, Chen Q, Zhang W.   +7 more
europepmc   +1 more source

Inter-species differences in wound-healing rate: a comparative study involving primates and rodents

Akiko Matsumoto–Oda, Daisuke Utsumi, Kenzo Takahashi, Satoshi Hirata, Atunga Nyachieo, Daniel Chai, Ngalla Jillani, M. Raymond   +7 more
openalex   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

Epidemiologic and Environmental Investigations of Reported Hantavirus Cases Inform Exposure Risk in California, 1993-2020. [PDF]

Am J Trop Med Hyg
Jackson BT, Kjemtrup AM, Novak MG, Fritz CL, Messenger S, Deldari M, Burns JE, Vugia DJ, Kramer VL.   +8 more
europepmc   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Rodent-Borne Parasites and Human Disease: A Growing Public Health Concern. [PDF]

Animals (Basel)
Rodriguez-Morales AJ, Shehata AA, Parvin R, Tasnim S, Duarte PM, Basiouni S.   +5 more
europepmc   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

COVID-19 lockdown effects on the foraging strategies of a facultative scavenger. [PDF]

Biol Lett
Catitti B, Chan YC, Farine DR, Oppel S, Orgeret F, Scherler P, Tschumi M, Witczak S, Grüebler MU.   +8 more
europepmc   +1 more source