Results 41 to 50 of about 684,295 (281)
Allocentric directional processing in the rodent and human retrosplenial cortex [PDF]
, 2014 Copyright © 2014 Knight and Hayman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or ...
Hayman, Robin, Knight, Rebecca
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Morphometric dataset of Varanus salvator for non-invasive sex identification using machine learning
Scientific DataReliable sex identification in Varanus salvator traditionally relied on invasive methods like genetic analysis or dissection, as less invasive techniques such as hemipenes inversion are unreliable.
Ariff Azlan Alymann +5 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Agriculture and forest rodent problems and control in Italy [PDF]
, 1986 Rodent pest problems and their control in Italy are reviewed. Two rats, Rattus norvegicus and Rattus rattus, and the field mouse, Apodemus sylvaticus, are often important pests both in rural and forestry areas.
Santini, Luciano A.
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Global Ecology and ConservationIn arid ecosystems, precipitation and temperature are two key factors, with altitude further shaping habitat conditions through its regulatory effects on temperature.
Qi-qige Buren +8 more
doaj +1 more source
Spatio-temporal home range of the dominant rodent species in Mabira central forest reserve, Uganda
BMC Ecology and Evolution, 2023 Background Rodents form the largest order among mammals in terms of species diversity, and home range is the area where an individual normally moves during its normal daily activities.
James Ssuuna +5 more
doaj +1 more source
Host-Dependent Clustering of Campylobacter Strains From Small Mammals in Finland
Frontiers in Microbiology, 2021 Small mammals are known to carry Campylobacter spp.; however, little is known about the genotypes and their role in human infections. We studied intestinal content from small wild mammals collected in their natural habitats in Finland in 2010–2017, and ...
Satu Olkkola +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source