Results 201 to 210 of about 9,726,866 (289)

Scaling Lassa Virus Dynamics within Anthropogenic Ecosystems (SCAPES) Study Protocol: a mixed-methods observational cohort study of humans, rodents, and landscapes in Nigeria. [PDF]

Wellcome Open Res
Friant S, Simons D, Harden C, Imirzian N, Bjornstad O, Gibb R, Jones K, Smith A, Thompson K, Lever A, Aderibigbe F, Ayambem W, Ifebueme N, Ignatius H, Koninga J, Meremikwu M, Moses L, Redding D.   +17 more
europepmc   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Molecular Detection, Epidemiology and Genetic Diversity of Babesia microti Infecting Wild Rodents. [PDF]

Vet Med Sci
Munir HM, Naeem M, Ijaz M, Ullah S, Usman M, Nasir ZUR, Khan A, Almaary KS, Bouallegue A, Mengistie AA, Iqbal F.   +10 more
europepmc   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Development of a Novel Quantitative PCR Assay for Detecting <i>Schistosoma japonicum</i> in Field-Captured Rodents. [PDF]

Pathogens
Lv C, Jia J, Xu X, Li S, Sun Q, Xu J, Lin L, Liu Q, Hong Y.   +8 more
europepmc   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

Correction to "Elastomeric Micro-Balloons for Remote Control of Cerebral Blood Flow and Real-Time In vivo Imaging of Rodent Brain Response to Hypoperfusion". [PDF]

Adv Mater
europepmc   +1 more source

Hantavirus Disease: A Comprehensive Narrative Review of Epidemiology, Pathogenesis, Diagnosis, and Treatment. [PDF]

Cureus
Ahmed A, Indawala M, Khan S, Kumar B, Chauhan S, M R M, Satodiya V, Tiwari RVC, Tiwari H.   +8 more
europepmc   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Metatranscriptomics reveals urbanization-driven divergence in rodent viromes and zoonotic risks in Chinese megacities. [PDF]

Commun Biol
Xiang ZF, Wang H, Yang F, Chen SJ, Huang TS, Wang SQ, Jiang ZH, Hu YY, Xiang M, Wang KX, Wang YZ, Huang YL, Li YR, Shi M, Hou W, Chen LJ.   +15 more
europepmc   +1 more source