Results 41 to 50 of about 2,405,598 (288)

Effect of inactivated nature‐derived microbial composition on mouse immune system

Immunity, Inflammation and Disease, 2022
Introduction The hygiene hypothesis suggests that decrease in early life infections due to increased societal‐level hygiene standards subjects one to allergic and autoimmune diseases.
Martín Ignacio González‐Rodríguez, Noora Nurminen, Laura Kummola, Olli H. Laitinen, Sami Oikarinen, Anirudra Parajuli, Tanja Salomaa, Iida Mäkelä, Marja I. Roslund, Aki Sinkkonen, Heikki Hyöty, Ilkka S. Junttila, for the ADELE Research Group   +12 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Socio-cultural factors influencing the adoption of ecologically based rodent pest management

, 2006
Ecologically based rodent pest management (EBRM) offers an alternative and more effective approach than the reactive use of rodenticides following high losses in rice crops. EBRM combines both cultural and physical rodent management practices, requires a
Huan, Nguyen Huu, Brown, Peter, Singleton, Grant, Palis, Florencia, Nga, Nguyen Thi Duong   +4 more
core   +1 more source

Global parasite and Rattus rodent invasions: The consequences for rodent‐borne diseases [PDF]

Integrative Zoology, 2015
AbstractWe summarize the current knowledge on parasitism‐related invasion processes of the globally invasive Rattus lineages, originating from Asia, and how these invasions have impacted the local epidemiology of rodent‐borne diseases. Parasites play an important role in the invasion processes and successes of their hosts through multiple biological ...
Morand, Serge, Bordes, Frédéric, Chen, Hsuan-Wien, Claude, Julien, Cosson, Jean-François, Galan, Maxime, Czirják, Gábor Á., Greenwood, Alex D., Latinne, Alice, Michaux, Johan, Ribas, Alexis   +10 more
openaire   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Intestinal Dysbiosis in, and Enteral Bacterial Therapies for, Systemic Autoimmune Diseases

Frontiers in Immunology, 2020
Recent studies have shown that a number of common autoimmune diseases have perturbations of their intestinal microbiome (dysbiosis). These include: Celiac Disease (CeD), Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Sjogren’s Syndrome (SS), and ...
Eric Marietta, Eric Marietta, Eric Marietta, Ashutosh K. Mangalam, Veena Taneja, Joseph A. Murray, Joseph A. Murray   +6 more
doaj   +1 more source

The microbiome and rodent models of immune mediated diseases

, 2021
Over the last six decades production of laboratory rodents have been refined with the aim of eliminating all pathogens, which could influence research results. This has, however, also created rodents with little diversity in their microbiota.
Hansen, Camilla Hartmann Friis, Hansen, Axel Kornerup   +1 more
core   +1 more source

Transgenic rodent models of Parkinson’s disease [PDF]

, 2009
In the case of Parkinson's disease (PD), classical animal models have utilized dopaminergic neurotoxins such as 6-hydroxydopamine (6OHDA) and 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (MPTP). More recently, human genetic linkage studies have identified several genes in familial forms of PD.
B K, Harvey, Y, Wang, B J, Hoffer
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

An analysis of rodent density patterns and its spatial–temporal correlations using geographically and temporally weighted regression in southeastern China

Frontiers in Veterinary Science
IntroductionRodents are significant vectors, harboring diverse pathogenic microorganisms which can spread a variety of infectious diseases. Surveillance on rodent density patterns should be prioritized as early warning indicators for prevention and ...
Mingyu Luo, Mingyu Luo, Jinna Wang, Jinna Wang, Mingyong Tao, Hanran Ji, Guoqin Jiang, Qinmei Liu, Qinmei Liu, Tianqi Li, Tianqi Li, Zhou Guan, Zhou Guan, Juan Hou, Juan Hou, Zhenyu Gong, Zhenyu Gong   +16 more
doaj   +1 more source