Results 151 to 160 of about 9,520,639 (370)

Use of large animal models to investigate Huntington's diseases

Cell Regeneration, 2019
Animal models that can mimic human diseases are the important tools for investigating the pathogenesis of the diseases and finding a way for treatment.
Sen Yan, Shihua Li, Xiao-Jiang Li
doaj  

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Cloning and Characterization of cDNAs Encoding a Candidate Glycogen Storage Disease Type 1b Protein in Rodents [PDF]

, 1998
Baochuan Lin, Borhane Annabi, Hisayuki Hiraiwa, Chi‐Jiunn Pan, Janice Y. Chou   +4 more
openalex   +1 more source

Superpixel Based Segmentation and Classification of Polyps in Wireless Capsule Endoscopy

, 2017
Wireless Capsule Endoscopy (WCE) is a relatively new technology to record the entire GI trace, in vivo. The large amounts of frames captured during an examination cause difficulties for physicians to review all these frames.
Maghsoudi, Omid Haji
core   +1 more source

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells

Advanced Science, EarlyView.
ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou   +15 more
wiley   +1 more source

Genospecies Diversity of Lyme Disease Spirochetes in Rodent Reservoirs [PDF]

, 1999
D. Richter, Stefan Endepols, Andreas Ohlenbusch, Helmut Eiffert, Andrew Spielman, Franz‐Rainer Matuschka   +5 more
openalex   +1 more source

Novel pathways of heart failure with preserved ejection fraction [PDF]

, 2016
INTRODUCTION: Diastolic heart failure (HF) i.e., HF with preserved ejection fraction (HFpEF) accounts for ~50% of all clinical HF presentations; but unlike systolic HF i.e., HF with reduced ejection fraction (HFrEF), there are no evidenced based ...
Li, Shanpeng
core   +1 more source

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, EarlyView.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

Rodent reservoirs: unraveling spectrum of zoonotic and pathogenic bacteria

Journal of Ideas in Health
Background: Zoonotic diseases are the major public health threat, with over 70% originating from wildlife. Rodents, while beneficial to the environment, transmit many zoonotic diseases such as hemorrhagic fevers, plague, tularemia, and leptospirosis ...
Agnes Mpinga , Rudovick Kazwala, Happiness Kumburu, Coletha Mathew   +3 more
doaj   +1 more source

A longitudinal study of an endemic disease in its wildlife reservoir: cowpox and wild rodents [PDF]

, 2000
Sarah M. Hazel, Malcolm Bennett, Julian Chantrey, Kevin J. Bown, Rachel D. Cavanagh, Trevor R. Jones, Derrick Baxby, Michael Begon   +7 more
openalex   +1 more source