Results 161 to 170 of about 2,514,304 (294)

Rising spillover risk: Lessons from the Andes hantavirus outbreak. [PDF]

One Health
Kong D.
europepmc   +1 more source

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

Advanced Science, EarlyView.
Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou, Jiwei Sun, Peng Chen, Caihong Mao, Junyuan Zhang, Haoqi Lei, Xiaoqing Han, Yaxuan Zhang, Yuheng Jiang, Yulin Jia, Bin Su, Lili Chen   +11 more
wiley   +1 more source

The uPAR/FPR antagonist UPARANT shows anti-angiogenic and antinflammatory properties in rodent models of retinal neovascular diseases.

, 2016
Treatment of retinal neovascular diseases by anti-VEGF based therapies has two major flaws: one third of patients respond poorly, and chronic depletion of VEGF may have neurotoxic effects.
Maurizio Cammalleri, Paola Bagnoli, Monica Aronsson, Mario De Rosa, Helder André, Anders P. Kvanta, Vincenzo Pavone, Massimo Dal Monte, Filippo Locri, Dario Rusciano, Liliana Lista   +10 more
core  

Integrated Analysis of Human Hemorrhagic Fever with Renal Syndrome Cases and Rodent Hantavirus Surveillance in Zhejiang Province, China, 2025. [PDF]

Viruses
Zhang R, Zheng QH, Zhou H, Xu F, Sun YS, Sun JM, Fang LQ, Wang LP.   +7 more
europepmc   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Climate change, rodent ecology, and the rising risk of hantavirus outbreaks: an alarming public health concern. [PDF]

Front Microbiol
Shrivastava SR, Bobhate PS, Mendhe H, Bankar N, Tidake A, Petkar P.   +5 more
europepmc   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

A multiregional serosurvey of RNA virus-reactive antibodies in bats and rodents reveals the enzootic presence of flavi- and paramyxoviruses in African Pteropodidae. [PDF]

PLoS Negl Trop Dis
Emanuel J, Papies J, Meiners L, Veith T, Corman VM, Binger T, Lattwein E, Kümmerer BM, Zweerink S, Fechner K, Gloza-Rausch F, Cottontail V, Maganga GD, Schmidt-Chanasit J, Vallo P, Oppong SK, Tschapka M, Reusken CBEM, Ulrich RG, Leroy EM, Drexler JF, Jones TC, Drosten C, Müller MA.   +23 more
europepmc   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Junín virus and Argentine haemorrhagic fever: Virology, pathogenesis, diagnosis, and prevention strategies. [PDF]

World J Virol
Karanam SK, Uppala PK, Kandra NV, Edhi S.   +3 more
europepmc   +1 more source