Results 81 to 90 of about 2,514,304 (294)

A single rapamycin dose protects against late-stage experimental cerebral malaria via modulation of host immunity, endothelial activation and parasite sequestration

Malaria Journal, 2017
Background Maladaptive immune responses during cerebral malaria (CM) result in high mortality despite opportune anti-malarial chemotherapy. Rapamycin, an FDA-approved immunomodulator, protects against experimental cerebral malaria (ECM) in mice through ...
Pedro Mejia, J. Humberto Treviño-Villarreal, Justin S. Reynolds, Mariana De Niz, Andrew Thompson, Matthias Marti, James R. Mitchell   +6 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Community-led intensive trapping reduces abundance of key plague reservoir and flea vector

Tropical Medicine and Health
Background Zoonotic pathogens transmitted by rodents are highly prevalent in low-middle income countries and effective control measures that are easily implemented are urgently needed.
Marcela P. A. Espinaze, Soanandrasana Rahelinirina, Todisoa Radovimiandrinifarany, Fehivola Mandanirina Andriamiarimanana, Alain Berthin Andrianarisoa, Voahangy Soarimalala, Kathryn Scobie, Mireille Harimalala, Minoarisoa Rajerison, Steven R. Belmain, Sandra Telfer   +10 more
doaj   +1 more source

Methods for Rodent Control to Prevent Zoonotic Diseases: A Systematic Review of Studies from Africa

Zoonotic Diseases
Background: Africa is a continent with diverse climates, landscapes, rainfall patterns, and vegetation types, all of which significantly influence its mammalian fauna, particularly small mammals.
Mwajabu Selemani, Abdul S. Katakweba, Shabani Kiyabo Motto, Rhodes H. Makundi   +3 more
doaj   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

Rodent species composition in urban and forested areas in eastern Germany [PDF]

Biodiversity Data Journal
Zoonoses are major concerns for public health and after the recent pandemic, have been under a global spotlight for their often unpredictable spread and rapid evolution.
Jasmin Firozpoor, Riccardo Gardini, Mario Escobar Huezo, Jana Eccard   +3 more
doaj   +3 more sources

Effectiveness of Ficus benjamina “Vaditi” and Artocarpus treculianus Elm. “Tipuho” Sap Extracts as Non-Chemical Rodent Trap

JPAIR, 2020
Pests are organisms that can cause economic damage or become threats to the health of humans and domestic animals. Rodents are pests and are considered to be essential reservoirs of numerous diseases that infect humans, domestic animals, and other ...
William Jo Se Billote, Paul Alcantara, Dean Eduard Cadid, Keenen Ivory Delos Reyes, Aira Marie Entela, Maria Angelica Gabotero, Ryan Ponce   +6 more
doaj   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Systematic surveillance tools to reduce rodent pests in disadvantaged urban areas can empower communities and improve public health

Scientific Reports
Rodents are notorious pests, known for transmitting major public health diseases and causing agricultural and economic losses. The lack of site-specific and national standardised rodent surveillance in several disadvantaged communities has rendered ...
Adedayo Michael Awoniyi, Ana Maria Barreto, Hernan Dario Argibay, Juliet Oliveira Santana, Fabiana Almerinda G. Palma, Ana Riviere-Cinnamond, Gauthier Dobigny, Eric Bertherat, Luther Ferguson, Steven Belmain, Federico Costa   +10 more
doaj   +1 more source

Effect of rodent density on tick and tick-borne pathogen populations: consequences for infectious disease risk

Parasites & Vectors, 2020
Background Rodents are considered to contribute strongly to the risk of tick-borne diseases by feeding Ixodes ricinus larvae and by acting as amplifying hosts for pathogens. Here, we tested to what extent these two processes depend on rodent density, and
Aleksandra I. Krawczyk, Gilian L. A. van Duijvendijk, Arno Swart, Dieter Heylen, Ryanne I. Jaarsma, Frans H. H. Jacobs, Manoj Fonville, Hein Sprong, Willem Takken   +8 more
doaj   +1 more source