Results 101 to 110 of about 2,514,304 (294)

Jennifer-Angoh/Pine-Marten-Rodent: v.1.0.1

<p>Code for article "How do microtine rodent abundance, snow and landscape parameters influence pine marten Martes martes population dynamics?".
Siow Yan Jennifer Angoh
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Critical analysis of translational potential of rodent models of white matter pathology across a wide spectrum of human diseases

Cell Death and Disease
Rodents are the most commonly used laboratory animals in medical research. However, significant evolutionary divergences between humans and rodents, particularly in the complexity of white matter connectome, which are fundamentally shaped by myelin as ...
Wenxuan Zhou, Shiyue Xia, Chenmeng Wang, Qingwu Yang, Alexei Verkhratsky, Jianqin Niu   +5 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

The Impacts of Climate Change on Water-, Food-, Vector- and Rodent-Borne Diseases [PDF]

, 2008
This chapter, The Impacts of Climate Change on Water-, Food-, Vector-, and Rodent-Borne Diseases, is from the book Human Health in a Changing Climate: A Canadian Assessment of Vulnerabilities and Adaptive Capacity edited by Jacinthe ...
Charron, Dominique, Fleury, Manon, Ogden, Nicholas, Schuster Wallace, Corinne, Lindsay, Robbin   +4 more
core  

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Chemical-Based Rodent Control Programs as a Zoonosis Control Measure: Proposal of Guidelines for Empirical Proof Studies

Rodent-borne diseases threaten global public health, impacting the urban poor. Despite widespread application of rodenticide in rodent/rodent-borne disease control programs, empirical evidence demonstrating their effectiveness is lacking.
Caio Graco Zeppelini, Zeppelini, Caio Graco,, Swedish University of Agricultural Sciences.   +2 more
core   +1 more source

Rodent-borne infections in rural Ghanaian farming communities

, 2019
Rodents serve as reservoirs and/or vectors for several human infections of high morbidity and mortality in the tropics. Population growth and demographic shifts over the years have increased contact with these mammals, thereby increasing opportunities ...
Fichet-Calvet, Elisabeth, Elisabeth Fichet-Calvet, Letizia, Andrew G., William K. Ampofo (447674), Karl C Kronmann, Andrew G. Letizia (6631325), Shirley C. Nimo-Paintsil (6631322), Randal J Schoepp, Shirley C Nimo-Paintsil, Mohareb, Emad, Emad Mohareb (433314), BORREMANS, Benny, Schoepp, Randal J., Elisabeth Fichet-Calvet (218214), Ampofo, William K., Benny Borremans, Bonney, Joseph H. K., Benny Borremans (3170499), Joseph H K Bonney, Karl C. Kronmann (317416), Andrew G Letizia, Nimo-Paintsil, Shirley C., Kronmann, Karl C., Obiri-Danso, Kwasi, Kwasi Obiri-Danso (5229659), Kwasi Obiri-Danso, Emad Mohareb, Randal J. Schoepp (628043), William K Ampofo, Joseph H. K. Bonney (6631328)   +29 more
core   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source