Results 181 to 190 of about 2,405,598 (288)

Group recognition in the German cockroach, a subsocial omnivore, is based on faecal odour preference that is modulated by coprophagy, diet and learning. [PDF]

Proc Biol Sci
Wada-Katsumata A, Hamilton JA, Kakumanu ML, Schal C.   +3 more
europepmc   +1 more source

Rodent models of Alzheimer's disease

Progress in Neurobiology
Alzheimer's disease (AD) was first described over a century ago. However, the mechanisms underlying the disease are not well understood to this day. This has negatively impacted our ability to create animal models to design and test targeted reliable treatments for the disease.
Singhaarachchi, Pasindu Hansana, Antal, Peter, Calon, Frédéric, Culmsee, Carsten, Delpech, Jean-Christophe, Feldotto, Martin, Geertsema, Jorine, Hoeksema, Emmy E., Korosi, Aniko, Layé, Sophie, McQualter, Jonathan, de Rooij, Susanne R., Rummel, Christoph, Slayo, Mary, Sominsky, Luba, Spencer, Sarah J.   +15 more
openaire   +2 more sources

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Spatiotemporal dynamics of the capture rate of Rattus tanezumi and its implications for rodent-borne diseases in the Three Gorges Reservoir Area, China. [PDF]

Environ Monit Assess
Xiao H, Liu Q, Su K, Wang Z, Tu T, Wei J, Ji H, Shang M, Ji H.   +8 more
europepmc   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Climate change and zoonotic spillover: lessons from recent hantavirus events. [PDF]

BMC Glob Public Health
Hu W, Gan T.
europepmc   +1 more source

Network „Rodent-borne pathogens“ in Germany: Longitudinal studies on the geographical distribution and prevalence of hantavirus infections

, 2007
Hartelt, U., Schlegel, M., Brockmann, S., Wenk, M., Wegener, W., Ulrich, Rainer G., Gerstengarbe, H. W., Pluta, S., Masur, D., Heckel, G., Pfeffer, M., Mikolajczak, S., Jacob, Jens, Sevke, K., Schmidt-Chanasit, J., Essbauer, S. S., Oehme, R., Pelz, Hans-Joachim, Mertens, M., Büchner, T.   +19 more
core  

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Emerging Mammarenaviruses in Wildlife: Expanding Host Range and Implications. [PDF]

Animals (Basel)
Di Martino B, Carnevale M, Corsi L, Sarchese V, Pellegrini F, Smoglica C, Petrini A, Martella V, Marsilio F, Di Profio F.   +9 more
europepmc   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source