Results 331 to 340 of about 9,442,226 (387)

Ancient evolutionary origins of hepatitis E virus in rodents. [PDF]

Proc Natl Acad Sci U S A
Jo WK, Anzolini Cassiano MH, de Oliveira-Filho EF, Brünink S, Yansanjav A, Yihune M, Koshkina AI, Lukashev AN, Lavrenchenko LA, Lebedev VS, Olayemi A, Bangura U, Salas-Rojas M, Aguilar-Setién Á, Fichet-Calvet E, Drexler JF.   +15 more
europepmc   +1 more source

First‐in‐Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN‐3143, a Novel Inhibitor of Mono‐Adenosine Diphosphate Ribosyltransferase‐PARP14

Clinical Pharmacology in Drug Development, EarlyView.
Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek, Alexandra Cole, Viviana Bozón, Erika Manyak, Jonathan Novak, Barbara Yang, Briohny A. Johnston, Sudha Parasuraman, Kushal J. Paneliya, Virna Schuck   +9 more
wiley   +1 more source

Intestinal helminths infection of Reithrodontomys mexicanus (Rodentia: Cricetidae) from a Suburban Area in Medellín, Colombia. [PDF]

Open Vet J
Llano HAB, Aguilar IL, Orozco NG, Giraldo LG, Zapata GS, Ruíz DG.   +5 more
europepmc   +1 more source

Identification of human metabolites of fast skeletal troponin activators Tirasemtiv and Reldesemtiv for doping control purposes

Drug Testing and Analysis, EarlyView.
The metabolism and urinary elimination of two substances recently classified as prohibited substances in sport was conducted, yielding suitable target analytes for efficient doping controls employing routinely applied chromatographic‐mass spectrometric test methods.
Luisa Euler, Kim Deinert, Felicitas Wagener, Katja Walpurgis, Mario Thevis   +4 more
wiley   +1 more source

Experimental modeling of Alzheimer's disease: Translational lessons from cross-taxon analyses. [PDF]

Alzheimers Dement
Yenkoyan KB, Kotova MM, Apukhtin KV, Galstyan DS, Amstislavskaya TG, Strekalova T, de Abreu MS, Chavushyan VA, Lim LW, Yang L, Rosemberg DD, Kalueff AV.   +11 more
europepmc   +1 more source

Beta2‐adrenergic agonist salbutamol exhibits enantioselective disposition in skeletal muscle of lean young men following oral administration

Drug Testing and Analysis, EarlyView.
Oral administration of salbutamol shows enantioselective disposition in human skeletal muscle, favoring the (S)‐enantiomer with higher relative partitioning of the pharmacologically active (R)‐enantiomer in muscle. This is concerning from an anti‐doping point of view because the anabolic properties demonstrated for salbutamol can potentially be ...
Morten Hostrup, Glenn A. Jacobson, Kasper Eibye, Christian K. Narkowicz, David S. Nichols, Søren Jessen   +5 more
wiley   +1 more source

<i>Peromyscus leucopus</i>, <i>Mus musculus</i>, and humans have distinct transcriptomic responses to larval <i>Ixodes scapularis</i> bites. [PDF]

Infect Immun
Bourgeois JS, McCarthy JE, Turk S-P, You SS, Bernard Q, Clendenen LH, Wormser GP, Marcos LA, Dardick K, Telford SR, Marques AR, Hu LT.   +11 more
europepmc   +1 more source

Squamate ventricular cardiomyocytes: Ploidy, proliferation, and heart muscle cell size in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Abstract Background While heart function is broadly conserved across vertebrates, the cellular phenotype of muscle cells (cardiomyocytes) varies across taxa and throughout ontogeny. Emerging evidence suggests that some attributes may correlate with the capacity for spontaneous cardiomyocyte replacement following injury.
Kathy Jacyniak, Karemna Barrera Jaimes, Minh Hanh Doan, Jordyn M. Chartrand, Matthew K. Vickaryous   +4 more
wiley   +1 more source

Noninvasive near-infrared live imaging of human adult mesenchymal stem cells transplanted in a rodent model of Parkinson&rsquo;s disease

, 2012
P Bossolasco, L Cova, G Levandis, Владимировна Экнадиосова Диана, S Cerri, Lambertenghi Deliliers G, E Polli, V Silani, F Blandini, Armentero MT   +9 more
openalex   +1 more source

<i>Bartonella</i> tracing in wild rodents in northwestern Mexico. [PDF]

Epidemiol Infect
Fernández-González AM, López-Pérez AM, Herrera-Mares A, Chaves A, Ramírez-Corona F, Suzán G.   +5 more
europepmc   +1 more source