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Fungal diseases of laboratory rodents
Veterinary Clinics of North America: Exotic Animal Practice, 2003Although fungal disease is uncommon in rodents, dermatophytosis is the most common mycosis seen in clinical practice. T. mentagrophytes is the most common etiologic agent, and the guinea pig is the most common species affected, although there are reports in all pet and laboratory rodent species except the gerbil.
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Rodent models for human diseases
European Journal of Pharmacology, 2015One of the factors limiting the translation of knowledge from preclinical studies to the clinic has been the limitations of in vivo diseases models. Except in the case of highly controlled and regulated clinical trials, geneticists and scientists do not use humans for their experimental investigations because of the obvious risk to life.
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Parkinson’s disease: a rethink of rodent models
Experimental Brain Research, 2006Parkinson's disease (PD) is a multifactorial disease with a complex etiology that results from genetic risk factors, environmental exposures and most likely a combination of both. Rodent models of parkinsonism aim to reproduce key pathogenic features of the syndrome including movement disorder induced by the progressive loss of dopaminergic neurons in ...
Heather L, Melrose +3 more
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Promising rodent models in Parkinson's disease
Parkinsonism & Related Disorders, 2018In the past decade, the study of the pathogenic mechanisms underlying neurodegeneration in Parkinson's disease (PD) has revealed a genetic component, often associated with a number of environmental risk factors. Animal models have improved our understanding of disease pathogenesis, providing significant insights into the understanding of novel ...
Imbriani P. +4 more
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Overview on Rodent Models of Alzheimer's Disease
Current Protocols in Neuroscience, 2005AbstractIn Alzheimer's disease (AD), characteristic lesions develop in brain regions that subserve cognitive functions, ultimately leading to dementia. There are now several lesioned or transgenic small‐animal models of the disease that model select aspects of cognitive deficits and/or recapitulate many, but not all, of the characteristic pathologic ...
Jean-Cosme, Dodart, Patrick, May
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Pharmacological Models of Parkinson’s Disease in Rodents
2011Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Despite the substantial progress that has been achieved, the precise mechanisms involved in the development of this disease are still not fully understood. The most common concepts relate to the genetic background and environmental/toxic effects.
Peter, Klivenyi, Laszlo, Vecsei
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In Practice, 2010
Pet rodents make up a small but significant part of the caseload in small animal veterinary practice. Skin disease is a frequent reason for presentation, as it is easily noticed by the owner, even in species that are not regularly handled. Particular problems encountered with the diagnosis and treatment of skin disease in rodents include the stress of ...
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Pet rodents make up a small but significant part of the caseload in small animal veterinary practice. Skin disease is a frequent reason for presentation, as it is easily noticed by the owner, even in species that are not regularly handled. Particular problems encountered with the diagnosis and treatment of skin disease in rodents include the stress of ...
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Cortical Plasticity in Alzheimer’s Disease in Humans and Rodents
Biological Psychiatry, 2007The aim of this study was to determine whether neocortical long-term potentiation (LTP) is deficient in patients with Alzheimer's disease (AD) and in amyloid precursor protein (APP)/presenilin-1 (PS1) mice, an AD animal model. We then ascertained whether this deficit might be paralleled by functional abnormalities of N-methyl-D-aspartate (NMDAR ...
BATTAGLIA F +6 more
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Genetic Rodent Models of Huntington Disease
2018The monogenic nature of Huntington disease (HD) has led to the development of a spectrum of useful genetically modified models. In particular, rodents have pioneered as the first HD model being generated and have since been the most widely used animal model for HD in both basic research and preclinical therapeutic studies.
J, Stricker-Shaver +3 more
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Protozoal diseases of rabbits and rodents
Seminars in Avian and Exotic Pet Medicine, 1995Protozoal parasites have been reported in rabbits and a variety of rodents. In many cases, the organisms are coincidental commensals, and no disease is present. In others, protozoa may cause problems as secondary invaders in debilitated/immunocompromised hosts or as primary pathogens.
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