Results 91 to 100 of about 2,614,376 (299)

Use of rodents as models of human diseases

Journal of Pharmacy And Bioallied Sciences, 2014
Advances in molecular biology have significantly increased the understanding of the biology of different diseases. However, these discoveries have not yet been fully translated into improved treatments for patients with diseases such as cancers. One of the factors limiting the translation of knowledge from preclinical studies to the clinic has been the
openaire   +3 more sources

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Systematic surveillance tools to reduce rodent pests in disadvantaged urban areas can empower communities and improve public health

Scientific Reports
Rodents are notorious pests, known for transmitting major public health diseases and causing agricultural and economic losses. The lack of site-specific and national standardised rodent surveillance in several disadvantaged communities has rendered ...
Adedayo Michael Awoniyi, Ana Maria Barreto, Hernan Dario Argibay, Juliet Oliveira Santana, Fabiana Almerinda G. Palma, Ana Riviere-Cinnamond, Gauthier Dobigny, Eric Bertherat, Luther Ferguson, Steven Belmain, Federico Costa   +10 more
doaj   +1 more source

Effect of rodent density on tick and tick-borne pathogen populations: consequences for infectious disease risk

Parasites & Vectors, 2020
Background Rodents are considered to contribute strongly to the risk of tick-borne diseases by feeding Ixodes ricinus larvae and by acting as amplifying hosts for pathogens. Here, we tested to what extent these two processes depend on rodent density, and
Aleksandra I. Krawczyk, Gilian L. A. van Duijvendijk, Arno Swart, Dieter Heylen, Ryanne I. Jaarsma, Frans H. H. Jacobs, Manoj Fonville, Hein Sprong, Willem Takken   +8 more
doaj   +1 more source

Ground-based rodent control in a remote Hawaiian rainforest on Maui. [PDF]

, 2008
Effective control of introduced mammalian predators is essential to the recovery of native bird species in Hawai‘i. Between August 1996 and December 2004, introduced rodents were controlled within three home ranges of the Po‘ouli Melamprosops phaeosoma,
Brosius, Christopher N., Groombridge, Jim J., Swinnerton, Kirsty J., Foster, Jeffrey T., Sparklin, Bill D., Vetter, John P., Malcolm, Trent R.   +6 more
core   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Rodent pest management in East Africa—an ecological approach

, 1999
Rodent Pest Management in East AfricaRodents are by far the greatest vertebrate pest problem in East Africa. They are responsible for substantial damage to food and cash crops, structures and industrial and domestic property.
Makundi, Rhodes H., Oguge, Nicholas O., Mwanjabe, Patrick S.   +2 more
core   +2 more sources

The Hidden Threat: Rodent-Borne Viruses and Their Impact on Public Health

Viruses
Rodents represent the most diverse order of mammals, comprising over 2200 species and nearly 42% of global mammalian biodiversity. They are major reservoirs of zoonotic pathogens, including viruses, bacteria, protozoa, and fungi, and are particularly ...
Awad A. Shehata, Rokshana Parvin, Shadia Tasnim, Phelipe Magalhães Duarte, Alfonso J. Rodriguez-Morales, Shereen Basiouni   +5 more
doaj   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Emerging rodent-borne viral pathogens in NE Italy: overview of seroprevalence and genomic investigations [PDF]

, 2018
Rodents play a key role as reservoirs of many zoonotic emerging infectious diseases which represent an emerging public health threat worldwide. The hazard posed by rodent-borne pathogens is often underestimated since most infections are asymptomatic in ...
Alfano, N., Rosso, F., Tagliapietra, V., Arnoldi, D., Hauffe, H. C., Rizzoli, A., Rossi, C.   +6 more
core   +1 more source