Results 51 to 60 of about 2,409,751 (295)

Mapping global risk of bat and rodent borne disease outbreaks to anticipate emerging threats

Scientific Reports
Future epidemics and/or pandemics may likely arise from zoonotic viruses with bat- and rodent-borne pathogens being among the prime candidates. To improve preparedness and prevention strategies, we predicted the global distribution of bat- and rodent ...
Soushieta Jagadesh, Claudia Cataldo, Wim Van Bortel, Esther Van Kleef, William Wint, Annapaola Rizzoli, Luca Busani, Elena Arsevska   +7 more
doaj   +1 more source

Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview

Frontiers in Neuroscience, 2021
The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide.
Andreza Fabro de Bem, Rachel Krolow, Hémelin Resende Farias, Victória Linden de Rezende, Daniel Pens Gelain, José Cláudio Fonseca Moreira, João Miguel das Neves Duarte, João Miguel das Neves Duarte, Jade de Oliveira   +8 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Knowledge, risk perceptions and practices regarding rodents and their associated pathogens: environmental consultants in Chile

One Health Outlook
Background Rodents play essential ecological roles but are also significant reservoirs of zoonotic pathogens, posing risks to humans. Individuals with frequent occupational contact with rodents face an elevated risk of exposure to rodent-borne diseases ...
Esteban Vásquez, Rodrigo Salgado, Hugo Mendoza, Diego A. Peñaranda, Darío Moreira-Arce, André V. Rubio   +5 more
doaj   +1 more source

A Remote Monitoring System for Rodent Infestation Based on LoRaWAN

Sensors, 2023
Rodent infestations are a common problem that can result in several issues, including diseases, damage to property, and crop loss. Conventional methods of controlling rodent infestations often involve using mousetraps and applying rodenticides manually ...
Shin-Chi Lai, Szu-Ting Wang, Kuan-Lin Liu, Chang-Yu Wu   +3 more
doaj   +1 more source

Rodent genetic models of Huntington disease

Neurobiology of Disease, 2008
Huntington disease (HD) is a dominantly inherited human neurodegenerative disorder characterized by motor deficits, cognitive impairment, and psychiatric symptoms leading to inexorable decline and death. Since the identification of the huntingtin gene and the characteristic expanded CAG repeat/polyglutamine mutation, multiple murine genetic models and ...
Mary Y. Heng, Peter J. Detloff, Roger L. Albin   +2 more
openaire   +3 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Rodent-Borne Parasites and Human Disease: A Growing Public Health Concern

Animals
Rodents are among the most widespread mammals globally and serve as critical reservoirs for a wide array of zoonotic parasites that significantly impact human health.
Alfonso J. Rodriguez-Morales, Awad A. Shehata, Rokshana Parvin, Shadia Tasnim, Phelipe Magalhães Duarte, Shereen Basiouni   +5 more
doaj   +1 more source

Use of large animal models to investigate Huntington's diseases

Cell Regeneration, 2019
Animal models that can mimic human diseases are the important tools for investigating the pathogenesis of the diseases and finding a way for treatment.
Sen Yan, Shihua Li, Xiao-Jiang Li
doaj   +1 more source

Metagenomic analysis of viromes in tissues of wild Qinghai vole from the eastern Tibetan Plateau

Scientific Reports, 2022
Rodents are natural reservoirs of diverse zoonotic viruses and widely distributed on the Tibetan Plateau. A comprehensive understanding of the virome in local rodent species could provide baseline of viral content and assist in efforts to reduce the risk
Xiaozhou He, Xu Wang, Guohao Fan, Fan Li, Weiping Wu, Zhenghuan Wang, Meihua Fu, Xu Wei, Shuo Ma, Xuejun Ma   +9 more
doaj   +1 more source