Results 121 to 130 of about 13,163,334 (326)

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

EBioMedicine, 2018
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH).
Ryan M. Esquejo, Christopher T. Salatto, Jake E. Delmore, Bina Albuquerque, A. Reyes, Yuji Shi, R. Moccia, E. Cokorinos, Matthew J. Peloquin, M. Monetti, Jason Barricklow, Eliza Bollinger, Brennan K. Smith, Emily A. Day, C. Nguyen, K. Geoghegan, J. Kreeger, A. Opsahl, Jessica L. Ward, A. Kalgutkar, D. Tess, L. Butler, N. Shirai, T. Osborne, G. Steinberg, M. Birnbaum, K. O. Cameron, Russell A. Miller   +27 more
semanticscholar   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Systematic surveillance tools to reduce rodent pests in disadvantaged urban areas can empower communities and improve public health

Scientific Reports
Rodents are notorious pests, known for transmitting major public health diseases and causing agricultural and economic losses. The lack of site-specific and national standardised rodent surveillance in several disadvantaged communities has rendered ...
Adedayo Michael Awoniyi, Ana Maria Barreto, Hernan Dario Argibay, Juliet Oliveira Santana, Fabiana Almerinda G. Palma, Ana Riviere-Cinnamond, Gauthier Dobigny, Eric Bertherat, Luther Ferguson, Steven Belmain, Federico Costa   +10 more
doaj   +1 more source

Use of rodents as models of human diseases

Journal of Pharmacy And Bioallied Sciences, 2014
Advances in molecular biology have significantly increased the understanding of the biology of different diseases. However, these discoveries have not yet been fully translated into improved treatments for patients with diseases such as cancers. One of the factors limiting the translation of knowledge from preclinical studies to the clinic has been the
openaire   +3 more sources

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Negative attitudes of an indigenous community are associated with lethal control of rodents in a temperate forest of Mexico

Ecological Solutions and Evidence
Rodents have been unwanted human commensals for millennia, as they can decimate crops and spread diseases. However, rodents perform essential ecological functions, and promoting awareness about this could boost native rodent conservation and increase ...
Margarita Gil‐Fernández, Diana Lucrecia Ruíz‐Ramírez, Johannes J. Le Roux, Christian A. Delfín‐Alfonso, M. Cristina MacSwiney G., Alexandra J. R. Carthey, Ross T. Shackleton   +6 more
doaj   +1 more source

The Hidden Threat: Rodent-Borne Viruses and Their Impact on Public Health

Viruses
Rodents represent the most diverse order of mammals, comprising over 2200 species and nearly 42% of global mammalian biodiversity. They are major reservoirs of zoonotic pathogens, including viruses, bacteria, protozoa, and fungi, and are particularly ...
Awad A. Shehata, Rokshana Parvin, Shadia Tasnim, Phelipe Magalhães Duarte, Alfonso J. Rodriguez-Morales, Shereen Basiouni   +5 more
doaj   +1 more source

Climate variability and change in the United States: potential impacts on vector- and rodent-borne diseases.

Environmental Health Perspectives, 2001
Diseases such as plague, typhus, malaria, yellow fever, and dengue fever, transmitted between humans by blood-feeding arthropods, were once common in the United States.
D. Gubler, P. Reiter, K. Ebi, W. Yap, R. Nasci, J. Patz   +5 more
semanticscholar   +1 more source

A Whole‐Head Finite Element Model for Electrical Neuromodulation via Visual Brain‐Machine Interfaces

Advanced Science, EarlyView.
A multimodal, personalized head model is presented that integrates the entire visual pathway with surrounding tissues to simulate electrical stimulation of the optic nerve. In vivo validation in humans and goats, plus systematic component‐elimination analysis, demonstrates the high accuracy of the comprehensive model.
Shengjian Lu, Tonghe Yang, Yuan Geng, Huan Wu, Yangrui Huang, Te Zheng, Haodi Chen, Shurui Huang, Yi Cao, Jian Yang, Wentao Yan, Yikui Zhang, Wencan Wu   +12 more
wiley   +1 more source

Association of rodent-borne Leptospira spp. with urban environments in Malaysian Borneo

PLoS Neglected Tropical Diseases, 2019
Although leptospirosis is traditionally considered a disease of rural, agricultural and flooded environments, Leptospira spp. are found in a range of habitats and infect numerous host species, with rodents among the most significant reservoirs and ...
K. Blasdell, Serge Morand, D. Perera, C. Firth   +3 more
semanticscholar   +1 more source