Results 41 to 50 of about 354,195 (312)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Du roi-prêtre au roi

Trajectoires, 2020
Le passage d’un pouvoir temporel séparé du pouvoir spirituel à une forme protestante de double pouvoir avec la sacralité du prince chef de son Église semble s’être fait dans l’urgence du contexte de la rupture de Luther avec la papauté romaine. L’article examine en détail comment cette nouvelle combinaison des deux pouvoirs trouve ses racines dans la ...
openaire   +3 more sources

A case report of malignant hypertension and multiorgan dysfunction during immunotherapy for gallbladder cancer

Frontiers in Oncology
We report the case of a 77-year-old woman with metastatic gallbladder cancer who initially received adjuvant capecitabine following surgery. During this period, she developed a facial rash, associated with a positive antinuclear antibody (ANA) with a ...
Caroline Anthon, Hugo Pierret, Frederic Houssiau, Selda Aydin, Astrid De Cuyper, Cédric Van Marcke, Marc Van Den Eynde, Filomena Mazzeo, Frank Cornelis, Rachel Galot, Francois P. Duhoux, Jean-François Baurain, Emmanuel Seront   +12 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

roi-r/Matlab_Codes_Karst_Caves: MATLAB_CODES_Cooling of hydrothermal fluids rich in carbon dioxide can create large karst cave systems in carbonate rocks

, 2023
Paper: Cooling of hydrothermal fluids rich in carbon dioxide can create large karst cave systems in carbonate ...
roi-r
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

A Discussion of Value Metrics for Data Repositories in Earth and Environmental Sciences

Data Science Journal, 2019
Despite growing recognition of the importance of public data to the modern economy and to scientific progress, long-term investment in the repositories that manage and disseminate scientific data in easily accessible-ways remains elusive.
Cynthia Parr, Corinna Gries, Margaret O'Brien, Robert R. Downs, Ruth Duerr, Rebecca Koskela, Philip Tarrant, Keith E. Maull, Nancy Hoebelheinrich, Shelley Stall   +9 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Digital Advertising System in Urban Transport System of Žilina Town

Transport and Telecommunication, 2014
The Internet and information and communication technologies (ICT) have changed everything: news, commerce, advertising, relating to others, getting information and transport too.
Madleňák Radovan, Madleňáková Lucia
doaj   +1 more source