Results 191 to 200 of about 3,708,197 (262)

Recovery-Limiting Signal-Conditioned Action Decoding for Emergency Wireless Access-Backhaul Capacity Allocation. [PDF]

Sensors (Basel)
Ma J, Han M, Ma H, Jin Y, Zhang Y.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

AI-based applications supporting informal caregivers in childhood caries prevention and management: protocol for a scoping review. [PDF]

BMJ Open
Anugrah PM, Emami E, Adiatman M, Darwita RRR.   +3 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Pandemic era expansion of state laws governing the professionalization of community health workers. [PDF]

Health Aff Sch
Weber-Fares R, Cheung T, Washburn DJ, Callaghan T, LaFleur M, Martinez D, Muthyala D, Warren K, Sage W, Schmit CD.   +9 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Association of a multiple risk factor assessment and intervention program with risk of diabetes: A population-based matched cohort study. [PDF]

PLoS Med
Bergman E, Nordström A, Nyberg L, Nordström P.   +3 more
europepmc   +1 more source

AI Therapy Chatbots in Youth With Attention-Deficit/Hyperactivity Disorder: A Nurse-Led, Risk-Tiered Policy Framework. [PDF]

Asian Pac Isl Nurs J
Ishibashi S, Kubota K.
europepmc   +1 more source