Results 81 to 90 of about 3,708,197 (262)

Methods of Information Subjects and Objects Interaction Rules Formalization in the Electronic Trading Platform System

Безопасность информационных технологий, 2015
The methods of information subjects and objects interaction rules formalization in the electronic trading platform system has been developed. They are based on mathematical model of mandatory role-based access control.
Emma Emanuilova Yandybaeva, Irina Vladimirovna Mashkina   +1 more
doaj  

Comparative analysis of identity management, access control, and authorization practices in public and private universities [version 2; peer review: 2 approved]

Open Research Europe
Background This research delves into the critical aspects of identity management, access control, and authorization practices within the domains of public and private universities.
Vesna Dimitrova, Elissa Mollakuqe
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Security Evaluation of Keycloak-Based Role-Based Access Control in Microservice Architectures Using the OWASP ASVS Framework

Journal of Applied Informatics and Computing
The Rocket Car Wash Semarang application operates using a microservice architecture that handles sensitive information such as user identity data, transaction history, and vehicle details.
Indra Gamayanto, Michael Christ Kurniawan, Gabriello Klavin Sanyoto   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Temporal Defeasible Role–Group–Task Access Control: A Logic-Based Framework for Explainable Authorization

IEEE Access
This paper introduces TDL-RGTA, a formal Temporal Defeasible Logic framework that enhances Role-Based Access Control (RBAC) by integrating organizational groups and contextual tasks into a dynamic, logic-based authorization model.
Hebah I. Abu Kaf, Khair Eddin Sabri, Nadim Obeid   +2 more
doaj   +1 more source