Results 41 to 50 of about 25,507,818 (312)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

EKSPLORASI IDENTITAS DIRI DAN PERAN PADA KAKEK-NENEK SEBAGAI CAREGIVER DARI ANAK DENGAN DISABILITAS

Jurnal Psikologi Undip, 2019
Being grandparents is an important role and valued in the family in which family members have a certain view of the existence of grandparents in the family especially about what will be taught to their grandchildren.
Dinie Ratri Desiningrum, Suryanto Suryanto   +1 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Investigation of the Role of Plasticizers in Film-forming Coats for Protecting Cooled Meat [PDF]

, 2018
As a result of theoretical studies on problems of protection and prolongation of storage terms of meat, it was revealed, that one of promising directions is to use protecting coats, based on natural biopolymers.The topicality of this study is in studying
Garbazhiy, K. (Kateryna), Kotlyar, E. (Evgenii), Kyshenia, A. (Andrii), Vinnikova, L. (Lydmila), Volovik, T. (Tat’yana)   +4 more
core  

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Shropshire's military, NHS, and volunteer community collaborate to provide an innovative training course for medical registrars.

Future Healthcare Journal
Introduction: •The position of Medical Registrar is one of the most important for the delivery of safe and effective emergency care in the acute hospital.
Kevin Eardley, Abigail Mackintosh, Gordon Wood   +2 more
doaj   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

The Role of Interior Design Elements in Attracting K-pop Lovers at Mujigae Restaurants in Bandung [PDF]

, 2019
The existence of Korean culture has become increasingly well-known by Indonesian people, it has become a venue for restaurant entrepreneurs to compete hard to win the hearts of consumers.
Hadiansyah, M. N. (Mahendra ), Rahmawati, W. W. (Wiwit ), Sari, M. N. (Mia )   +2 more
core  

Role Ambiguity in Sport Teams [PDF]

, 2003
The general purpose of the present study was to examine the nature of role ambiguity in sport teams and to explore the construct validity of the operational definition of role ambiguity developed by Beauchamp, Bray, Eys, and Carron (2002). Role ambiguity
Beauchamp, Mark R., Bray, Steven R., Carron, Albert V., Eys, Mark A.   +3 more
core   +3 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source