Results 41 to 50 of about 169,391 (259)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Role of Village Government in Combating Illegal Gold Mining (PETI) at the Batang Teso Irrigation Dam, Marsawa Village, Riau

Jurnal Ilmu Administrasi Negara
Illegal gold mining without a permit (PETI) at the Batang Teso Irrigation Dam in Marsawa Village, Kuantan Singingi Regency, Riau Province, has become a serious environmental and social issue due to its destructive impacts and lack of government ...
Lilis Tri Marsa, Hazqon Fuadi Nasution
doaj   +1 more source

Book review: Mining and community in South Africa: From small town to iron town Edited by: Lochner Marais, Philippe Burger and Deidre van Rooyen

Town and Regional Planning, 2019
Mining has dominated the development in South Africa for over a century. Although the South African economy is no longer dependent on the mining industry, this book clearly indicates that the mining industry still plays (and will continue to play) an ...
Juanee Cilliers
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The mechanism of the gold loan and its use in the gold mining industry

Известия высших учебных заведений: Геология и разведка, 2017
The essence of the gold loan and its role in the formation of the market of the precious metals have been considered. The gold mining companies are stated to be the main users of the borrowed gold.
V. T. Borisovich, Z. M. Nazarova, B. S. Madzhidov   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Les intermédiaires locaux dans la topographie politique de la gouvernance minière au Cameroun

EchoGéo
Mining regulatory reform in Cameroon has encouraged the involvement of mining companies in semi-mechanised artisanal mining, and the state has adopted a form of indirect governance of security in extractive territories.
Merlin Ottou
doaj   +1 more source

Quality improvement of mining specialists tarining on the basis of cooperation between Saint-Petersburg mining university and Orica company

Записки Горного института, 2017
The analysis of practical solutions for a joint cooperation between the Mining University and the Australian company Orica resulted in the decision of creation a Competence center in the field of mining.
M. N. Overchenko, M. A. Marinin, S. P. Mozer   +2 more
doaj   +1 more source