Results 101 to 110 of about 18,453,462 (297)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Using Role Models and Game-Based Learning to Attract Adolescent Girls to STEM
Education SciencesVarious pedagogical approaches have been proposed to attract more female students to STEM (science, technology, engineering, and mathematics), targeting student beliefs and perceptions that are linked to STEM study intentions.
Ioanna Vekiri +2 more
doaj +1 more source
The status of minority ethnic teachers in England: Institutional racism in the staffroom
DEDiCA, 2011 This paper reports research conducted with Black and Minority Ethnic (BME) teachers in England, specifically to find out (i) whether the status of teaching influenced their decisions to join the profession, and (ii) their perceptions of their status ...
Linda M. Hargreaves
doaj +1 more source
Model Federation based on Role Modeling
Proceedings of the 7th International Conference on Model-Driven Engineering and Software Development, 2019 Modeling approaches could be a powerful solution for specification, design and analysis. At a system level, models must take into account many system concerns. Thus, several system modeling approaches are based on several viewpoints expressed in Domain Specific Modeling Languages.
Bastien Drouot, Joël Champeau
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
BMJ, 1998 We are none of us saints, and a veneer of sophistication and restraint is all that lies between us and the unbridled satiation of our most venal appetites and our most primitive drives; to eat, to survive, to have sex, to reproduce, to ensure the perpetuation of our own genes.
openaire +3 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source