Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Impact of Participation in Role-Playing Game (RPG) Sessions on the Perceived Level of Social Anxiety and Received Social Support. [PDF]
Brain SciKroplewski Z, Łoś R, Pawlicki BJ.
europepmc +1 more source
Phubbing and Social Intelligence: Role-Playing Experiment on Bystander Inaccessibility. [PDF]
Int J Environ Res Public Health, 2021 Mantere E, Savela N, Oksanen A.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Investigating the Influence of Role-Playing on Empathy and Perspective-Taking by Analyzing Level of Engagement, Emotional, and Cognitive Processes Through a Word Count Analysis Approach. [PDF]
Perspect Med EducTien YM +4 more
europepmc +1 more source
Use of virtual reality compared to the role-playing methodology in basic life support training: a two-arm pilot community-based randomised trial. [PDF]
BMC Med Educ, 2023 Figols Pedrosa M +4 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Hierarchically Structured Role-Playing Simulation as a Tool for Promoting Soft Skills in Veterinary Undergraduates. [PDF]
Animals (Basel)Perez-Ecija A +3 more
europepmc +1 more source
Using peer role-playing to improve students' clinical skills for musculoskeletal physical examinations. [PDF]
BMC Med Educ, 2021 Yamauchi K +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source