Results 251 to 260 of about 11,777 (278)
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Journal of Cardiovascular Pharmacology, 2004
The aim of this study was to compare the positive inotropic effects of 3 different agents with 3 different mechanisms of actions-levosimendan, rolipram, and dobutamine-on human atrial trabecular muscles. Samples of right atrial appendage (1 cm, 500-1000 mg) were removed and immersed in preoxygenated and modified Tyrode solution.
Coskun Usta +8 more
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The aim of this study was to compare the positive inotropic effects of 3 different agents with 3 different mechanisms of actions-levosimendan, rolipram, and dobutamine-on human atrial trabecular muscles. Samples of right atrial appendage (1 cm, 500-1000 mg) were removed and immersed in preoxygenated and modified Tyrode solution.
Coskun Usta +8 more
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Emetic, central nervous system and pulmonary activities of rolipram in the dog
European Journal of Pharmacology, 1995Rolipram was characterized for its emetic, behavioral, cardiovascular and pulmonary activities in dogs, to assess its systemic pharmacology and potential bronchodilatory selectivity. At doses > or = 0.1 mg/kg i.v., rolipram induced emesis, anxiety, and stepping behaviors in conscious dogs, and increased heart rate and cardiac contractility in ...
Deborah Y. Evans, Richard J. Heaslip
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Stimulation of renin secretion by the phosphodiesterase IV inhibitor rolipram.
The Journal of Pharmacology and Experimental Therapeutics, 1996It is now generally accepted that the renin secretory response to beta adrenoceptor stimulation is mediated by increased formation of cAMP in the juxtaglomerular cells. It is also known that renin secretion is increased when cAMP metabolism is decreased by phosphodiesterase inhibitors such as theophylline, but it is not known which isoforms of ...
N, Chiu, I, Park, I A, Reid
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Sensitivity of a cAMP PDE to Rolipram in Different Organs
1987Manipulation of cAMP-dependent mechanisms in aminergic transmission by selective phosphodiesterase (PDE) inhibitors may provide a novel therapetic approach for the management of depression (Wachtel, 1983). The PDE inhibitor rolipram has been shown in recent clinical trials to possess antidepressant activity (Horowski and Sastre, 1985).
Gudrun Pahlke +2 more
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Continuous-Flow Multistep Synthesis of (R)- and (S)-Rolipram [PDF]
Synfacts, 2015 H Oyamada, Shu Kobayashi, T Tsubogo
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