Results 61 to 70 of about 7,547 (235)

Postinjury treatment with rolipram increases hemorrhage after traumatic brain injury [PDF]

Journal of Neuroscience Research, 2012
AbstractThe pathology caused by traumatic brain injury (TBI) is exacerbated by the inflammatory response of the injured brain. Two proinflammatory cytokines that contribute to inflammation after TBI are tumor necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β).
C M, Atkins, Y, Kang, C, Furones, J S, Truettner, O F, Alonso, W D, Dietrich   +5 more
openaire   +2 more sources

Biomaterial‐Based Emergency Intervention for Secondary Spinal Cord Injury

Small Science, Volume 5, Issue 11, November 2025.
Emergency intervention using advanced biomaterials targets key pathological mechanisms to block secondary spinal cord injury (SCI) by inhibiting inflammation, reducing excitotoxicity, restoring the blood−spinal cord barrier, and limiting scar formation, which provides significant neural protection and promotes neural regeneration, offering promising ...
Jincheng Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu, Jianxun Ding   +5 more
wiley   +1 more source

Rolipram stimulates angiogenesis and attenuates neuronal apoptosis through the cAMP/cAMP-responsive element binding protein pathway following ischemic stroke in rats.

Experimental and Therapeutic Medicine, 2016
Rolipram, a phosphodiesterase-4 inhibitor, can activate the cyclic adenosine monophosphate (cAMP)/cAMP-responsive element binding protein (CREB) pathway to facilitate functional recovery following ischemic stroke.
Shouye Hu, Qingwen Cao, P. Xu, W. Ji, G. Wang, Yue-Lin Zhang   +5 more
semanticscholar   +1 more source

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

MedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan, Sana Khurshid, Saud Almawash, Rakesh Kumar, Ammira S. Al‐Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +6 more
wiley   +1 more source

Effects of PDE4 Pathway Inhibition in Rat Experimental Stroke

Journal of Pharmacy & Pharmaceutical Sciences, 2014
PURPOSE: The first genomewide association study indicated that variations in the phosphodiesterase 4D (PDE4D) gene confer risk for ischemic stroke. However, inconsistencies among the studies designed to replicate the findings indicated the need for ...
Fan Yang, Rachita K Sumbria, Dong Xue, Chuanhui Yu, Dan He, Shuo Liu, Annlia Paganini-Hill, Mark Fisher   +7 more
doaj   +1 more source

Rolipram as a Discriminative Stimuli: Transfer to Phosphodiesterase Inhibitors

Japanese Journal of Pharmacology, 1987
Rats were trained to discriminate (+/-)-rolipram (0.32 mg/kg, i.p.) from saline in a two-lever food-reinforced drug discrimination procedure (FR 10). (+/-)-Rolipram served as a drug discriminative stimulus, and its discrimination was readily established with a mean of 42 training sessions to achieve criterion performance (at least 80% correct response ...
T, Yamamoto, K, Miyamoto, S, Ueki
openaire   +2 more sources

6‐Nitrodopamine Release From Mouse Seminal Vesicles Is Dependent on Endothelial Nitric Oxide Synthase (eNOS) Activation

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
ABSTRACT Human seminal vesicles present basal release of epithelium‐derived 6‐nitrodopamine (6‐ND) and this catecholamine potentiates noradrenaline‐induced contractions. Since nitric oxide synthase (NOS) activation is a determining factor involved in 6‐ND biosynthesis, this study aimed to investigate which NOS isoform is responsible for the 6‐ND ...
José Britto‐Júnior, Pérola Rafaella Cedano Godoy, Denis Oliveira Lima, Valéria B. de Souza, André A. Schenka, Fernanda V. Mariano, Felipe Fernandes Jacintho, Idam Hermawan, Hiroaki Shimokawa, Masato Tsutsui, Silvana Chiavegatto, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Nitrergic Signaling Mediation of Neurobehavioral Responses to Stress in Zebrafish

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Nitric oxide (NO) production is regulated by a plethora of upstream mediators, including glutamate, serotonin, and inflammatory mediators, at both neurons and non‐neuronal cells. These mediators are regulated by stressors, and their activity can increase or decrease NO production in a nitric oxide synthase (NOS) isoform‐dependent way.
João Alphonse Apóstolo Heymbeeck, Eveline Bezerra de Sousa, Monica Lima‐Maximino, Antonio Pereira Jr., Caio Maximino   +4 more
wiley   +1 more source

Efecto del inhibidor de fosfodiesterasa tipo 4 -rolipram, sobre la maduración in vitro de oocitos bovinos Efeito do inibidor de fosfodiesterasa tipo 4 -rolipram, sobre a maturação in vitro de oocitos bovinos Effect of phosphodiesterase type 4-inhibitor rolipram on in vitro maturatrion of bovine oocytes

Revista Colombiana de Ciencias Pecuarias, 2008
Durante el proceso de maduración in vitro de oocitos, las gonadotropinas FSH y LH inducen la producción de AMPc. El AMPc tiene efecto dual, donde los altos niveles de AMPc intraoocitario mantienen su bloqueo meiótico, mientras que en las células de la ...
Yuddy S López, Ana M Mejía, Elder E Escobar, Bernardo Agudelo Jaramillo, Neil A Vásquez Araque, Hernán Echavarría   +5 more
doaj  

Mechanisms of cyclic nucleotide phosphodiesterases in modulating T cell responses in murine graft-versus-host disease. [PDF]

PLoS ONE, 2013
Graft-versus-host disease (GvHD) is a key contributor to the morbidity and mortality after allogeneic hematopoetic stem cell transplantation (HSCT). Regulatory Foxp3(+) CD4(+) T cells (Treg) suppress conventional T cell activation and can control GvHD ...
Michael Weber, Corinna Lupp, Pamela Stein, Andreas Kreft, Tobias Bopp, Thomas C Wehler, Edgar Schmitt, Hansjörg Schild, Markus P Radsak   +8 more
doaj   +1 more source