Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease [PDF]
, 2017 Huntington’s disease (HD) is a polyglutamine (polyQ) disease caused by aberrant expansion of the polyQ tract in Huntingtin (HTT). While motor impairment mediated by polyQ-expanded HTT has been intensively studied, molecular mechanisms for nonmotor ...
Akira Sawa +31 more
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Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells [PDF]
, 2012 Cyclic AMP (cAMP) is the archetypal smooth muscle relaxant, mediating the effects of many hormones and drugs. However, recently PGI2, acting via cAMP/PKA, was found to increase contraction-associated protein expression in myometrial cells and to promote ...
Amsen +35 more
core +2 more sources
Phosphodiesterase 4B: Master Regulator of Brain Signaling
Cells, 2020 Phosphodiesterases (PDEs) are the only superfamily of enzymes that have the ability to break down cyclic nucleotides and, as such, they have a pivotal role in neurological disease and brain development. PDEs have a modular structure that allows targeting
Amy J. Tibbo, George S. Baillie
doaj +1 more source
Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration
Cells, 2021 Synaptic plasticity events, including long-term potentiation (LTP), are often regarded as correlates of brain functions of memory and cognition. One of the central players in these plasticity-related phenomena is the α-amino-3-hydroxy-5-methylisoxazole-4-
Faraz Ahmad +3 more
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Molecular Imaging and Biology, 2018 PurposePhosphodiesterase 4 (PDE4) inhibition in the brain has been reported to improve cognitive function in animal models. Therefore, PDE4 inhibitors are one of key targets potential for drug development. Investigation of brain PDE4 occupancy would help
A. Takano +8 more
semanticscholar +1 more source
Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory [PDF]
, 2016 Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial ...
Abel, Ted +13 more
core +4 more sources
Stereospecificity of rolipram actions on eosinophil cyclic AMP-specific phosphodiesterase [PDF]
Biochemical Journal, 1993 The stereospecificity of rolipram inhibition of particulate cyclic AMP-specific phosphodiesterase (PDE IV) from guinea-pig eosinophils has been investigated. (-)-Rolipram (IC50 = 0.22 +/- 0.08 microM) was 2.5-fold more potent than (+)-rolipram (IC50 = 0.58 +/- 0.05 microM) in inhibiting membrane-bound PDE IV. Solubilization of PDE IV with deoxycholate (
L C Scott, J E Souness
openaire +3 more sources
International Journal of Molecular Medicine, 2016 Bone cancer pain (BCP) is one of the most difficult and intractable tasks for pain management, which is associated with spinal 'neuron-astrocytic' activation.
Chi-hua Guo +7 more
semanticscholar +1 more source
Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages. [PDF]
, 2018 Macrophage migration is an essential step in host defense against infection and wound healing. Elevation of cAMP by inhibiting phosphodiesterase 4 (PDE4), enzymes that specifically degrade cAMP, is known to suppress various inflammatory responses in ...
Catherine Jin, S-L +7 more
core
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]
, 2007 Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Bolger, G.B. +8 more
core +1 more source