Results 21 to 30 of about 856 (188)

Molecular Basis of NPY Recognition and Ligand Selectivity at the Neuropeptide Y5 Receptor

Angewandte Chemie, EarlyView.
Here, we present the first active structure of the neuropeptide Y5 receptor (NPY5R) in complex with its endogenous ligand NPY and the Gi1 protein. The cryo‐electron microscopy structure, validated by extensive mutagenesis studies, gives important insights into the molecular mechanisms underlying ligand binding and receptor activation.
Lisa Christin Peuker, Hongyu Wang, Kun Chen, Kristin Löbner, Karin Mörl, Simon Jonas Schwarz, Qiang Zhao, Beili Wu, Annette Gabriele Beck‐Sickinger   +8 more
wiley   +2 more sources

Elucidating Liquid‐Phase Guest Transport Across MOF Single Crystals: Interplay of Adsorption, Desorption, and Intracrystalline Diffusion

Angewandte Chemie, EarlyView.
Guest transport across metal–organic framework (MOF) single crystals disentangles transport occurring through the micropores from contributions at grain boundaries. Even guest molecules with identical kinetic diameters show drastically different transport behavior arising from the distinct modes of adsorption. Neither pore clogging nor surface collapse
Hochul Woo, Hans Roman Cortina, Adam J. Matzger   +2 more
wiley   +2 more sources

Vertex–Edge Roman {2}-Domination

Mathematics
A vertex–edge Roman {2}-dominating function on a graph G=(V,E) is a function f:V⟶{0,1,2} satisfying that, for every edge uv∈E with f(v)=f(u)=0, ∑w∈N(v)∪N(u)f(w)≥2. The weight of the function f is the sum ∑a∈Vf(a). The vertex–edge Roman {2}-domination number of G, denoted by γveR2(G), is the minimum weight of a vertex–edge Roman {2}-dominating function ...
Ahlam Almulhim, Saiful Rahman Mondal
openaire   +2 more sources

The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells

Advanced Science, EarlyView.
Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato, Jesús A. Andrés‐San Román, Juan Garrido‐García, Carmen Gordillo‐Vázquez, Ana M. Palacios, Elisabeth Lidueña‐Fernández, Katie McDole, Pedro Gómez‐Gálvez, Valentina Annese, Luis M. Escudero   +9 more
wiley   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source

Metaheuristic algorithms for solving roman {2}-domination problem

RAIRO - Operations Research
A Roman {2}-dominating function (Rom2DF) on a graph G(V, E) is a function g : V → {0, 1, 2} of G such that for every vertex x ∈ V with g(x) = 0, either there exists a neighbor y of x with g(y) = 2 or at least two neighbors, u, v with g(u) = g(v) = 1. The value w(g) = ∑x∈V g(x) is the weight of the Rom2DF.
M. Alfred Raju, P. Venkata Subba Reddy 0001   +1 more
openaire   +1 more source

Experimental Demonstration of Temporally Aware Fault‐Tolerant Sensor Fusion Using Memristive Associative Learning

Advanced Electronic Materials, EarlyView.
In dynamic driving scenarios, the proposed approach ensures only temporally aligned sensor inputs to make driving decisions, preventing false activations. By enabling selective hardware‐level learning, it achieves fast, reliable responses under noisy conditions.
Kapil Bhardwaj, Ashfak Nehal, Dmitrii Semenov, Roman Sotner, Sayani Majumdar   +4 more
wiley   +1 more source

Nickel‐Free Perovskite Solar Cells Enabled by Self‐Assembled Monolayers: A Pathway to Efficient and Recyclable Devices

Advanced Energy Materials, EarlyView.
Replacing toxic NiOx with phenyl‐substituted phosphonic‐acid carbazole monolayers (Ph‐5PACz) yields inverted perovskite solar cells that are efficient and recyclable. The nickel‐free interface reaches 25.3% efficiency and enables closed‐loop ITO recovery with near‐98% performance retention, while life‐cycle and techno‐economic analyses confirm lower ...
Yanxue Wang, Roman Kučera, Sinuhé Perea‐Puente, Mykhailo Sytnyk, Andrew Hainer, Zijian Peng, Savannah Bennett, Juan S. Rocha‐Ortiz, Albert These, Hakan U Dag, Qi Fan, Anastasia Barabash, Zhenni Wu, Chaohui Li, Jens Hauch, Olga Kasian, Christoph J. Brabec, Ian Marius Peters   +17 more
wiley   +1 more source