Results 51 to 60 of about 1,461,446 (283)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

l Congresso Internazionale “La grandezza della vita quotidiana” (2002) / The International Congress “The Grandeur of Ordinary life” [PDF]

open access: yesStudia et Documenta, 2008
In January 2002, for the celebration of the centennial of the birth of St. Josemaría, an international congress with the title “The Grandeur of Ordinary Life” took place. The publication of the event, in fourteen volumes, gives us an idea of the richness
Miguel Ángel Ortiz
doaj   +1 more source

Generalized $\mathbb{Z}_2\times \mathbb{Z}_2$ in Scaling neutrino Majorana mass matrix and baryogenesis via flavored leptogenesis

open access: yes, 2017
We investigate the consequences of a generalized $\mathbb{Z}_2\times\mathbb{Z}_2$ symmetry on a scaling neutrino Majorana mass matrix. It enables us to determine definite analytical relations between the mixing angles $\theta_{12}$ and $\theta_{13 ...
Ghosal, Ambar   +2 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

Bioclimatic Conditions of Paris, Rome and Budapest on the Basis of the Universal Thermal Climate Index

open access: yesMiscellanea Geographica: Regional Studies on Development, 2010
The aim of this study was to examine the main features of the bioclimatic conditions of three European cities using a new Universal Thermal Climate Index.
Idzikowska Danuta
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo   +12 more
wiley   +1 more source

Рим Гоголя: авторские чтения повести как факт творческой истории

open access: yesAvtobiografija, 2015
Gogol’s Rome: The Author’s Readings of the Tale as Part of its Creative Process The present article is devoted to the public reading of the tale Rome done by Gogol’ in Rome in March and in December 1839 at some acquaintances’ home, and in Moscow in ...
Yuri Mann
doaj   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas   +39 more
wiley   +1 more source

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