Results 271 to 280 of about 1,269,288 (364)

Synergistic Anti‐Cancer Therapy Through Ultrasound‐Induced Piezocatalytic Therapy and Tumor Treatment Fields

open access: yesAdvanced Science, EarlyView.
A novel, wearable anti‐cancer platform synergistically combines tumor treating fields (TTFs) and piezocatalytic therapy (PCT) via ultrasound‐activated, lead‐free piezocomposites. This strategy efficiently suppresses tumor growth, modulates the immune microenvironment, and demonstrates strong therapeutic synergy in both mouse model of subcutaneous tumor
Jing Jin   +9 more
wiley   +1 more source

Modulating a Massive Set of Biomolecular Structures by Sono‐Mechanical Force

open access: yesAdvanced Science, EarlyView.
Using low‐power ultrasound exposure, picoNewton forces are generated to release loaded drugs after unfolding secondary structures in DNA nanoassemblies. This opens a door to reversibly manipulate a large set of biomolecular structures both inside and outside cells without the damages incurred by high‐power sonications currently used in the field ...
Pravin Pokhrel   +7 more
wiley   +1 more source

Li/Al‐LDH Reinforced Polyacrylamide/Xanthan Gum Semi‐Interpenetrating Network Nano‐Conductive Hydrogels for Stress Sensing and Wearable Device Applications

open access: yesAdvanced Science, EarlyView.
PXL hydrogel is prepared by in situ polymerization of acrylamide (AM) between Li/Al‐LDH nanosheets and forming a semi‐interpenetrating network structure with xanthan gum (XG). The in situ polymerization of AM ensures the uniform distribution of Li/Al‐LDH within the hydrogel network.
Zhiwei Hu   +16 more
wiley   +1 more source

Intracellular Mechanical Stress‐Mediated Autophagy Cell Death via Nanospikes for Cancer Treatment

open access: yesAdvanced Science, EarlyView.
Nanospikes with tunable morphology at the nanoscale induce lysosomal membrane damage by generating localized mechanical stress, activating Galectin‐3 (Gal3)‐Trim16‐mediated autophagic cell death. Finite element analysis and laser‐triggered spike ablation enable precise control of intracellular force signaling and cytotoxicity, offering a ...
Yingze Li   +11 more
wiley   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

open access: yesAdvanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu   +12 more
wiley   +1 more source

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