Results 101 to 110 of about 1,671,484 (281)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Investigation of the causes of maternal mortality using root cause analysis in Isfahan, Iran in 2013-2014

Iranian Journal of Nursing and Midwifery Research, 2015
Background: Many maternal deaths caused are due to preventable causes during pregnancy and childbirth. Therefore, the detailed analysis of the root causes provides developing a plan and appropriate interventions to prevent these deaths occurring in the ...
Marjan Beigi, Somaye Bahreini, Mahboubeh Valiani, Mojtaba Rahimi, Azar Danesh-Shahraki   +4 more
doaj  

Prevalence Trends and Influencing Factors for Post-stroke Cognitive Impairment in China: a Meta-analysis [PDF]

Zhongguo quanke yixue
Background Post-stroke cognitive impairment (PSCI) is a common sequela of stroke that severely impacts patients' quality of life and is often overlooked.
ZHAO Xuejiao, LI Juan, LI Yujie, LU Ting, Xian Lihong, YAN Huan
doaj   +1 more source

Analisis Gangguan Sistem Transmisi Listrik Menggunakan Metode Root Cause Analysis (Rca) [PDF]

, 2014
Public lifestyle nowdays is very dependent on the availability of electrical power and PT. PLN. (PERSERO) is the sole provider of electricity in Indonesia. Data PT.
Rumita, R. (Rani), Suliantoro, H. (Hery), Widyastuti, L. N. (Luh)   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Contribution of Indirect Causes to Maternal Mortalities Based on a Methodological Approach to Clinical Epidemiology in Iran [PDF]

International Journal of Travel Medicine and Global Health, 2013
Introduction: Level of mothers’ literacy, pregnancy history of more than four times, residence in villages, lack of receiving intensive care during pregnancy, as well as inaccessibility to obstetric emergency services have been reported, in Iran and the ...
Mahmoud Mobasheri, Ali Ahmadi, Babak Eshrati, Mehdi Noroozi, Leila Lashkari   +4 more
doaj  

Root Cause Analysis and Health Informatics

, 2016
Root Cause Analysis (RCA) is the most widely used system analysis tool for investigating safety related incidents in healthcare. This contribution reviews RCA techniques, using a Health Informatics example, and discusses barriers to their successful uptake by healthcare organisations. It is concluded that a critical assessment to examine the uptake and
Jones, Richard W., Despotou, George
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

On the Use of Spatial Graphs for Performance Degradation Root-Cause Analysis Toward Self-Healing Mobile Networks

IEEE Access
On the road to the sixth generation of cellular networks (6G), the need to ensure a sustainable usage of natural resources, amid increased competition and cost pressures, has driven the adoption of text Self-Healing Mobile Networks to enhance operational
Luis Mata, Marco Sousa, Pedro Vieira, Maria Paula Queluz, Antonio Rodrigues   +4 more
doaj   +1 more source