Results 61 to 70 of about 6,896,512 (318)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mean and standard deviation (SD) of normalized root-mean-square error function (F_NRMSE) in controls and multiple sclerosis (MS) patients.

, 2019
Mean and standard deviation (SD) of normalized root-mean-square error function (FNRMSE) in controls and multiple sclerosis (MS) patients.
M. C. Alonso-Rodríguez (6555950), L. De Santiago (7841240), L. Boquete (7841225), E. M. Sánchez Morla (6555941), E. Garcia-Martin (7841249), J. M. Miguel-Jiménez (7841234), M. Ortiz del Castillo (7841243), A. López-Dorado (7841246), E. Vilades (7841231), L. E. Pablo (7841237), E. López-Guillén (7841228)   +10 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

“Smart agriculture: a climate-driven approach to modelling and forecasting fall armyworm populations in maize using machine learning algorithms”

Frontiers in Plant Science
The fall armyworm (Spodoptera frugiperda) poses a significant threat to global maize production owing to its rapid life cycle, extensive host range, and strong dispersal capabilities. We developed a forecasting system for fall armyworm outbreaks over one
Vani Sree Kalisetti, Upendhar Sudharshanam, Nagesh Kumar Mallela Venkata, Rajashekhar Mandla, Srinivas Akula, Mallaiah Bedika, Bhadru Dharavath, Sreelatha Dogga, Ramakrishna Babu A, Chandrasekhar Javaji   +9 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

The Wiener RMS (Root Mean Square) Error Criterion in Filter Design and Prediction

, 1949
This chapter contains sections titled: 1 Linear Filters, 2 Minimization of RMS Error, 3 Determination of the Weighting Function, 4 Realization of Operator—Mathematical Formulation, 5 RC Filter, 6 Prediction and Lag with and without ...
N. Wiener
semanticscholar   +1 more source

Root mean square error difference of joint rotation.

, 2021
Average (mean ± SD) root mean square error difference of the maximum ankle joint rotation, at four different positions (0–9 cm) and two different conditions (fixed = filled bars, free = empty bars).
Savvas Stafilidis (7022657), Carina Kopper-Zisser (11361867)   +1 more
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source