Results 111 to 120 of about 5,596,672 (396)
PLoS Computational Biology, 2010 Every new scientific discipline or methodology reaches a point in its maturation where it is fruitful for it to turn its gaze inward, as well as backward. Such introspection helps to clarify the essential structure of a field of study, facilitating communication, pedagogy, standardization, and the like, while retrospection aids this process by ...
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FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
RACINE2: A software application for processing spatial distribution of root lenght density from intersections on trench profiles [PDF]
, 2009 A field method has been developed to quantify root length density (RLD) from root intersection density (RID) measured on a trench-profile, using modelling RID-RLD relationships.
Chopart, Jean-Louis +2 more
core
, 2006 A wide range of counting and occurrence constraints can be specified with just two global primitives: the Range constraint, which computes the range of values used by a sequence of variables, and the Roots constraint, which computes the variables mapping onto a set of values. We focus here on the Roots constraint.
Bessiere, Christian +4 more
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From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Historia Mathematica, 1979 AbstractCombinatorics has been rather neglected by historians of mathematics. Yet there are good reasons for studying the origins of the subject, since it is a kind of mathematical subculture, not exactly parallel in its development with the great disciplines of arithmetic, algebra, and geometry.
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Sweetpotato (SP-30) Flakes: Process Optimization and Moisture Adsorption Isotherm Studies
Annals of Tropical Research, 2014 Sweetpotato is one of the predominant crops grown by local farmers in the marginal uplands of Brgy. Linao, Sitio Batuan, Inopacan, Leyte. The need to produce quality food products from sweetpotato is a continuing challenge to open new opportunities for ...
Julie D. Tan +2 more
doaj +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Microbial Biotechnology, 2009 The biochemical and functional analysis of proteins with unknown functions can be a difficult task and needs endurance and the knowledge of sometimes ‘old‐fashioned’ methods. Even more, without a sequenced genome, it takes a long time to identify the DNA sequence coding for the protein of interest.
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FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source