Results 141 to 150 of about 5,860,679 (396)

Heritable variation in root secondary metabolites is associated with recent climate [PDF]

open access: bronze, 2020
Zoe Bont   +4 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

DEVELOPMENT OF SWEETPOTATO-BASED FERMENTED BEVERAGE

open access: yesAnnals of Tropical Research, 1997
The optimum time for fermentation and suitable fermenting container was established for the production of sweetpotato-based fermented beverage Evaluation of the beverage was done through physicochemical and sensory analyses by trained panelists.
Julie D. Tan, Edna E. Forio
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

EFFECTS OF LAND PREPARATION AND POSTPLANTING TILLAGE ON WEED CONTROL AND CASSAVA YIELD

open access: yesAnnals of Tropical Research, 1987
Two experiments were conducted to determine the effect of land preparation and postplanting tillage on weed control and cassava yield. The first experiment showed that weed biomass and cassava yield were not affected by the method of land preparation ...
Federico G Villamayor Jr   +1 more
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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