Results 71 to 80 of about 1,285,891 (313)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Historia Mathematica, 1979 AbstractCombinatorics has been rather neglected by historians of mathematics. Yet there are good reasons for studying the origins of the subject, since it is a kind of mathematical subculture, not exactly parallel in its development with the great disciplines of arithmetic, algebra, and geometry.
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FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Sweetpotato (SP-30) Flakes: Process Optimization and Moisture Adsorption Isotherm Studies
Annals of Tropical Research, 2014 Sweetpotato is one of the predominant crops grown by local farmers in the marginal uplands of Brgy. Linao, Sitio Batuan, Inopacan, Leyte. The need to produce quality food products from sweetpotato is a continuing challenge to open new opportunities for ...
Julie D. Tan +2 more
doaj +1 more source
, 2006 A wide range of counting and occurrence constraints can be specified with just two global primitives: the Range constraint, which computes the range of values used by a sequence of variables, and the Roots constraint, which computes the variables mapping onto a set of values. We focus here on the Roots constraint.
Bessiere, Christian +4 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Microbial Biotechnology, 2009 The biochemical and functional analysis of proteins with unknown functions can be a difficult task and needs endurance and the knowledge of sometimes ‘old‐fashioned’ methods. Even more, without a sequenced genome, it takes a long time to identify the DNA sequence coding for the protein of interest.
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