Results 261 to 270 of about 1,673,414 (364)

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Efficacy of Endodontic Files in Root Canal Retreatment: A Systematic Review of In Vitro Studies. [PDF]

J Funct Biomater
Soler-Doria A, Sanz JL, Maddalone M, Forner L.   +3 more
europepmc   +1 more source

Extracellular Vesicle‐Packaged circTAX1BP1 from Cancer‐Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells

Advanced Science, EarlyView.
This study reveals that CAFs‐derived EVs enriched with circTAX1BP1 drive CRLM by promoting VIRMA lactylation and SP1/TGF‐β signaling, creating a positive feedback loop via ITGA11+ myCAFs. Targeting EV‐circTAX1BP1 and TGF‐β disrupts this loop, offering a novel therapeutic strategy for CRLM.
Jia‐nan Tan, Jin‐hao Yu, Dong Hou, Ye‐quan Xie, Dong‐ming Lai, Fang Zheng, Bin Yang, Jin‐tao Zeng, Yang Chen, Shu‐hong Lu, Guang‐yu Zhong, Fang‐hai Han, Sheng‐ning Zhou   +12 more
wiley   +1 more source

Preoperative dental anxiety across menstrual cycle phases in women undergoing root canal treatment. [PDF]

Sci Rep
Çoban Öksüzer M, Hatipoğlu Ö, Şanal Çıkman A, Pertek Hatipoğlu F.   +3 more
europepmc   +1 more source

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Advanced Science, EarlyView.
Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li   +6 more
wiley   +1 more source

Immediate Esthetic Build-Up (IEB) for Anterior and Premolar Teeth During Root Canal Therapy. [PDF]

Cureus
Temsah AA.
europepmc   +1 more source

Antioxidant Carbon Dot of Selenomethionine Alleviates Oxidative Stress in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A selenomethionine‐derived carbon dot (Se‐Met‐CD) serves as a potent nano‐antioxidant, efficiently scavenging reactive oxygen species, protecting nucleus pulposus cells from oxidative damage, restoring extracellular matrix homeostasis, and significantly mitigating intervertebral disc degeneration in vivo, which demonstrates great promise as a nanozyme ...
Qingzheng Zhang, Zongtai Liu, Yirong Sun, Changfeng Fu, Jianxun Ding   +4 more
wiley   +1 more source

Effect of Orthodontic Movement on the Periapical Healing of Teeth Undergone Endodontic Root Canal Treatment: A Systematic Review. [PDF]

J Clin Med
Alharbi H, Almutairi MS, Alrajhi S, Almotairy N.   +3 more
europepmc   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, EarlyView.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Effect of scaling and root planing on root canal-treated teeth with periodontal pockets. [PDF]

Bioinformation
Rajpoot AS, Baghel D, Choubey V, Kaur J, Gupta D, Bansal R, Kumari A.   +6 more
europepmc   +1 more source