Results 81 to 90 of about 1,454,360 (340)

Antibody‐Programmable Bimetallic Nanozymes for Transcriptional Blockade Therapy in HER2/ER‐Positive Breast Cancer

Advanced Functional Materials, EarlyView.
Zr‐Fe MOF@Ribociclib@Herceptin (ZFRH) efficiently targets/kills Human Epidermal Growth Factor Receptor 2/Estrogen Receptor‐positive (HER2/ER+) breast cancer cells. It combats tumors by: 1) Elevating ROS, altering redox balance; 2) Inhibiting transcription; 3) Inducing pyroptosis.
Hongkun Miao, Tong Ye, Mingjiang Liu, Jingchao Gao, Lian Tan, Qian Dong, Qingbo Lv, Qianqian Ye, Yu Wang   +8 more
wiley   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Current trends in technological armamentarium and treatment among Brazilian endodontists

Brazilian Journal of Oral Sciences, 2017
Aim: To determine the current trends in technological armamentarium and endodontic treatment among Brazilian endodontists. Methods: A total of 279 endodontists answered a web-based survey questionnaire about their region of activity in Brazil and years ...
Ana Cristina Garcia Ferreira, Marcos Frozoni, Maíra Prado, Brenda Gomes, Fernanda Signoretti, Adriana De-Jesus-Soares   +5 more
doaj   +1 more source

Surface Wrinkling of Plasma‐Exposed PDMS is Caused by Water Vapor Sorption: An Optical Environmental Sensor

Advanced Functional Materials, EarlyView.
Wrinkling of soft materials, such as polydimethylsiloxane (PDMS), underpins a myriad of technologies. Plasma‐oxidation of PDMS induces spontaneous wrinkling, which is canonically attributed to thermal expansion‐contraction of bilayers. Employing experiments and modelling, it is demonstrated that sorption of water vapor is instead responsible for ...
Zain Ahmad, Gunjan Tyagi, Shuning Xiang, Jerry Heng, Pedro Patrício, Paulo I. C. Teixeira, Christopher M. Stafford, Jack F. Douglas, João T. Cabral   +8 more
wiley   +1 more source

Engineering Highly Cellularized Living Materials via Mechanical Agitation

Advanced Functional Materials, EarlyView.
A mechanical agitation strategy is developed to engineer highly cellularized living materials, achieving cell densities of up to 1 billion cells per milliliter. By precisely tuning properties such as stiffness and toughness in blood clots, the approach is validated in both in vitro and in vivo studies.
Aram Bahmani, Shiyu Liu, Evan Johnston, Weiyi Wan, Xiaoyi Lan, Tianqin Ning, Alexander Nottegar, Ran Huo, Shuaibing Jiang, Jianyu Li   +9 more
wiley   +1 more source

A study of root canal morphology in maxillary third molars using cone⁃beam computed tomography

口腔疾病防治, 2017
Objective This study investigated root canal morphology in maxillary third molars by CBCT to provide an anatomical guideline for clinical treatment. Methods CBCT images of 397 maxillary third molars were collected.
QUAN He, WANG Dan, YUAN Jie
doaj   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Mixture tetracycline citric acid and detergent – A root canal irrigant. A review

Journal of Oral Biology and Craniofacial Research, 2013
Background: Root canal irrigants play an indispensable role for the complete disinfection of the root canal system, in particular those areas of the root canal that are not accessible for instrumentation.
G.P.V. Srikumar, K.S. Sekhar, K.G. Nischith   +2 more
doaj  

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

A Case Report on Endodontic Management of a Rare Vertucci Type III Maxillary Canine

Case Reports in Dentistry, 2019
Success in root canal treatment demands a thorough knowledge of usual root canal anatomy and its variations pertaining to every tooth. Variations in root canal anatomy are often accompanied by complex orientation of pulp tissues making a thorough ...
Hrudi Sundar Sahoo, R. Kurinji Amalavathy, D. Pavani   +2 more
doaj   +1 more source