Results 181 to 190 of about 1,467,829 (302)

Uniaxial Strain‐Driven Ferroelastic Domain Tuning in LaAlO3${\rm LaAlO}_3$

Advanced Science, EarlyView.
The present work demonstrates based on AFM, μ$\umu$‐Raman spectroscopy, XRD, and first‐principles, that uniaxial strain provides a handle for tuning the ferroelastic domain populations in lanthanum aluminate, driving a continuous and controlled phase transition from a four‐variant rhombohedral crystal system to a two‐variant orthorhombic crystal system
Matthias Roeper, Robin Buschbeck, Jakob Wetzel, Tobias Ritschel, Anna‐Lena Hofmann, Vladyslav Kovtunovych, Mike N. Pionteck, Javier Taboada‐Gutiérrez, Alexey B. Kuzmenko, Martina Basini, Vivek Unikandanunni, Iuliia Kiseleva, Jochen Geck, Susanne C. Kehr, Maximilian Lederer, Simone Sanna, Lukas M. Eng, Samuel D. Seddon   +17 more
wiley   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Evaluation of mandibular and maxillary second molar root canal anatomy in a Turkish subpopulation using CBCT: comparison of Briseno-Marroquin and Vertucci classifications. [PDF]

BMC Med Imaging
Güneç HG, Öreroğlu İ, Çağlar K, Cesur Aydin K.   +3 more
europepmc   +1 more source

Micro-CT study of the root canal anatomy of maxillary canines. [PDF]

J Clin Exp Dent, 2017
Plascencia H, Cruz Á, Palafox-Sánchez CA, Díaz M, López C, Bramante CM, Moldauer BI, Ordinola-Zapata R.   +7 more
europepmc   +1 more source

Suppressing Photothermal Artifacts in Flexible Fluorescent Fiber‐Optic Sensors for Accurate and Precise In Situ Temperature Monitoring

Advanced Science, EarlyView.
A partial‐inner‐cladding optical fiber (PICOF) is developed to suppress photothermal artifacts in fluorescent fiber‐optic thermometry by isolating the sensing layer from regions prone to photothermal effects. This structural design strategy enables high‐fidelity operation at elevated excitation power, achieving high accuracy (maximum absolute error ...
Sijie Su, Jinjian Yu, Pengyuan Dong, Xin Wang, Jing Lyu, Jiulin Gan, Enhai Song, Qinyuan Zhang   +7 more
wiley   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source