Results 41 to 50 of about 1,467,829 (302)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A Case Report on Endodontic Management of a Rare Vertucci Type III Maxillary Canine
Case Reports in Dentistry, 2019 Success in root canal treatment demands a thorough knowledge of usual root canal anatomy and its variations pertaining to every tooth. Variations in root canal anatomy are often accompanied by complex orientation of pulp tissues making a thorough ...
Hrudi Sundar Sahoo +2 more
doaj +1 more source
Mandibular left first premolar with two roots: A morphological oddity
Contemporary Clinical Dentistry, 2012 Thorough knowledge of the root canal morphology, appropriate assessment of the pulp chamber floor, and critical interpretation of radiographs are a prerequisite for successful root canal therapy.
Nitin Kararia +2 more
doaj +1 more source
Rare Variation in Root Canals of Mandibular, Canine and Premolar Teeth
RUHS Journal of Health Sciences, 2023 One of the main causes of failure of root canal treatment is failure to diagnose variations in root canal anatomy. Hence, diagnosing the correct root canal morphology is critical for successful endodontic treatment.
Deepika Sharma, Y S Hada; Himani Choudhary; Tarun Tiwari
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
International Journal of Dentistry, 2021 Aim. To investigate the root canal anatomy of Burmese (Myanmar) permanent maxillary first molar (BMFM) with micro-computed tomography. Methodology. One hundred and one extracted BMFMs were scanned by a SkyScan 1272 scanner (Bruker microCT, Belgium) and ...
M. M. Kyaw Moe +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Root canal preparation with FlexMaster: asessment of torque and force in relation to canal anatomy [PDF]
International Endodontic Journal, 2003 AbstractAim To investigate physical parameters of FlexMaster nickel‐titanium instruments while preparing curved canals in maxillary molars in vitro.Methodology A torque‐testing platform was used to prepare root canals in 11 extracted human maxillary molars with FlexMaster rotary instruments.
Hubscher, W, Barbakow, F, Peters, O A
openaire +7 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Clinical Case ReportsKey Clinical Message Due to the complexities and variations of the root canal system's anatomy, mandibular premolars are among the most difficult teeth for endodontic treatment.
Sholeh Ghabraei +2 more
doaj +1 more source