LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang+15 more
wiley +1 more source
ProTaper files in root canal preparation: Case report
The aim of this paper was to, on the basis of everyday clinical practice, show and analyse, the crown-down technique of root canal preparation with nickel-titanium rotary instruments. After the diagnosis of irreversible pulp disease on the second lower right molar, endodontic treatment was carried out.
openaire +3 more sources
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li+3 more
wiley +1 more source
Identification of the Procedural Accidents During Root Canal Preparation Using Digital Intraoral Radiography and Cone Beam Computed Tomography [PDF]
K.-Ivácson A.- Csinszka+4 more
openalex +1 more source
Effects of the endodontic access cavity on apical debris extrusion during root canal preparation using different single-file systems [PDF]
Pelin Tüfenkçi+2 more
openalex +1 more source
Analysis of instrumentation protocols, preparation quality and final cleaning of the root canal in mandibular molars [PDF]
Flávia Darius Vivacqua
openalex +1 more source
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li+8 more
wiley +1 more source
Comparative Evaluation of Dentinal Crack After Root Canal Preparation Using TruNatomy, Neoendo Flex, and Neoendo Neohybrid Files: An In Vitro Study. [PDF]
Priyadarshni P+5 more
europepmc +1 more source
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen+9 more
wiley +1 more source