Results 191 to 200 of about 106,751 (354)

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Micro-CT evaluation of frozen and embalmed human cadavers on the effect of root canal preparation on microcrack formation in old dentin. [PDF]

PLoS One, 2023
Haupt F, Dullin C, Krebs M, Hettwer-Steeger I, Kanzow P, Rödig T.   +5 more
europepmc   +1 more source

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

Advanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai   +11 more
wiley   +1 more source

Variable Taper Nickel-Titanium Rotary Instrument Technique

Saudi Endodontic Journal, 2011
Removal of all organic debris and microorganisms from the root canal system, and shaping the root canal space is a very important step in root canal therapy. This will facilitate adequate irrigation and filling of the entire root canal space. A number of
Khalid S Al-Fouzan
doaj  

Effect of Simultaneous Working Length Control During Root Canal Preparation Versus Electronic Apex Locator on Postoperative Pain in Teeth with Symptomatic Irreversible Pulpitis (A Randomized Clinical Trial)

, 2021
Aml Mohammed Abdel Moteleb, Heba Elasfouri, Shaimaa Ismail Gawdat   +2 more
openalex   +1 more source

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation

Advanced Science, EarlyView.
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu, Hongtao Song, Limin He, Zhihao Hu, Yu Li, Chao Xu, Shaojie Liu, Jun Jiang, Yike Zhou, Zhengxuan Li, Zeyu Li, Keying Zhang, Shuaijun Ma, Ruochen Qi, Shichao Han, Changhong Shi, Weihong Wen, Donghui Han, Weijun Qin   +18 more
wiley   +1 more source

Radicular dentinal microcracks during biomechanical root canal preparation using four minimally invasive endodontic files. [PDF]

Med Pharm Rep, 2022
Bilaiya S, Patni PM, Jain P, Raghuwanshi S, Pandey SH, Harinkhere C.   +5 more
europepmc   +1 more source

Scanning Electron Microscopic and Dye Penetration Evaluation of Hand Instrumentation Techniques on Formation of Smear Layer in Root Canal Preparation: An In vitro Study

, 2021
Vineet Galhotra, Ankur Chauhan, Sagar Mohkar, Amit Heda, Govind Nandkumar Agrawal, Aniket Chavan   +5 more
openalex   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley   +1 more source

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source