Results 301 to 310 of about 178,289 (369)
Long‐term immunosuppression of rabbits through oral tacrolimus administration
Oral gavage of rabbits with 1.5 mg/kg/d of tacrolimus allows for an efficient long‐term (1 year) immunosuppression with minimal side effects and no loss of animals. lmmunosuppressed rabbits are a convenient animal model to investigate the long‐term efficacy of human allografts in vivo.
Alexane Thibodeau+4 more
wiley +1 more source
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu+3 more
wiley +1 more source
Engineered Hydrogels Revolutionize Locoregional Cancer Immunotherapy
This review systematically summarizes the latest research progress on injectable hydrogels in cancer immunotherapy, highlighting their unique advantages in precise immune activation, local drug‐controlled release, and immune microenvironment remodeling. These features provide innovative solutions to overcome the bottlenecks of systemic side effects and
Jiyong Wei+3 more
wiley +1 more source
Structured Lipids: Synthesis, Genetic Engineering, and Applications
ABSTRACT Lipids are essential to the human body, but some can be harmful. As a result, current research focuses on structured lipids (SLs), which are engineered to have specific fatty acid arrangements. These structural modifications can enhance both nutritional and physical properties.
Chandu S. Madankar+5 more
wiley +1 more source
Predicting ecology and hearing sensitivities in Parapontoporia—An extinct long‐snouted dolphin
Abstract Analyses of the cetacean (whale and dolphin) inner ear provide glimpses into the ecology and evolution of extinct and extant groups. The paleoecology of the long‐snouted odontocete (toothed whale) group, Parapontoporia, is primarily marine with its depositional context also suggesting freshwater tolerance.
Joyce Sanks, Rachel Racicot
wiley +1 more source
Bioimaging of the sense organs and brain of fishes and reptiles. Left panel: 3D reconstruction of the head and brain of the deep‐sea viperfish Chauliodus sloani following diceCT. Right panel: A 3D reconstruction of a 70‐day‐old embryo head of the bearded dragon Pogona vitticeps following diceCT, showing the position of the segmented brain within the ...
Shaun P. Collin+9 more
wiley +1 more source
Abstract The trigeminus nerve (cranial nerve V) is a large and significant conduit of sensory information from the face to the brain, with its three branches extending over the head to innervate a wide variety of integumentary sensory receptors, primarily tactile.
Juri A. Miyamae+4 more
wiley +1 more source
Abstract Computed tomography (CT) enables rapid imaging of large‐scale studies of bone, but those datasets typically require manual segmentation, which is time‐consuming and prone to error. Convolutional neural networks (CNNs) offer an automated solution, achieving superior performance on image data.
Andrew H. Lee+3 more
wiley +1 more source
Early life functional transitions impact craniofacial morphology in osteogenesis imperfecta
Abstract Early life behaviors have a profound role in shaping adult craniofacial morphology. During early life, all mammals undergo the dynamic transition from suckling to mastication, a period coinciding with rapid cranial biomineralization. Osteogenesis imperfecta (OI), a genetic disorder that impacts the production of type I collagen, disrupts ...
Courtney A. Miller+2 more
wiley +1 more source
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley +1 more source