Results 51 to 60 of about 106,751 (354)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Prediction of thrust force and torque in canal preparation process using Taguchi method and Artificial Neural Network

open access: yesAdvances in Mechanical Engineering, 2021
Root canal preparation is a vital procedure during the treatment of pulposis and periapical periodontitis. However, the improper control of thrust force and torque in root canal preparation will cause nerve damage and cell necrosis. The aim of this study
Weihao Guo   +5 more
doaj   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

open access: yesMolecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin   +10 more
wiley   +1 more source

Antimicrobial effectiveness of polyhexamethylene biguanide on Enterococcus faecalis, Staphylococcus epidermidis and Candida albicans [PDF]

open access: yesMedicinski Glasnik, 2018
Aim To evaluate the antimicrobial activity of 0.2% polyhexamethilene biguanide (PHMB) in root canal models infected with Enterococcus faecalis, Candida albicans and Staphylococcus epidermidis. PHMB was compared in these tests with 2.5% NaOCl and 0.2% CHX.
Ivana Medvedec Mikić   +6 more
doaj   +1 more source

Is it safe to use YouTube (TM) to learn about root canal preparation? Analysis of content and quality of videos [PDF]

open access: yes, 2023
Aim: This study assessed the quality, educational content, and demographics of root canal preparation videos on YouTube (TM). Methodology: The study was performed for root canal preparation using the keywords "root canal shaping," "root canal preparation,
Falakaloğlu, Seda   +3 more
core   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

open access: yesMolecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa   +14 more
wiley   +1 more source

ProTaper Rotary Instrument Fracture During Root Canal Preparation: A Comparison Between Rotary and Hybrid Techniques [PDF]

open access: yes, 2013
AIMS: This study aimed to compare the frequency of ProTaper rotary instrument fracture with rotary (conventional) and hybrid (rotary and hand files) canal preparation techniques.
Farid, Huma   +2 more
core   +1 more source

Root canal preparation with FlexMaster: asessment of torque and force in relation to canal anatomy [PDF]

open access: yesInternational Endodontic Journal, 2003
AbstractAim  To investigate physical parameters of FlexMaster nickel‐titanium instruments while preparing curved canals in maxillary molars in vitro.Methodology  A torque‐testing platform was used to prepare root canals in 11 extracted human maxillary molars with FlexMaster rotary instruments.
Ove A. Peters   +3 more
openaire   +5 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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