Results 71 to 80 of about 178,289 (369)

Shaping ability of four root canal instrumentation systems in simulated 3D-printed root canal models. [PDF]

open access: yesPLoS ONE, 2018
INTRODUCTION:The aim of this study was to compare the shaping ability of four root canal preparation systems in newly developed 3D-printed root canal models.
David Christofzik   +5 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Kedo file system for root canal preparation in primary teeth

open access: yesIndian Journal of Dental Research, 2019
Endodontic instruments play a vital role during root canal preparation. Biomechanical preparation in primary teeth is performed using the adult endodontic files. There are various disadvantages during use of adult endodontic files in primary teeth namely
G. Jeevanandan   +2 more
semanticscholar   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

open access: yesMolecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo   +11 more
wiley   +1 more source

A comparative study of cyclic fatigue of 6 endodontic systems. An in vitro study [PDF]

open access: yes, 2022
Mechanical preparation and the formation of space for adequate obturation are included in root canal shaping, but the complex root canal anatomy may be affect it.
Aranda, Susana   +4 more
core   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

Root canal preparation with FlexMaster: asessment of torque and force in relation to canal anatomy [PDF]

open access: yesInternational Endodontic Journal, 2003
AbstractAim  To investigate physical parameters of FlexMaster nickel‐titanium instruments while preparing curved canals in maxillary molars in vitro.Methodology  A torque‐testing platform was used to prepare root canals in 11 extracted human maxillary molars with FlexMaster rotary instruments.
Ove A. Peters   +3 more
openaire   +5 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

open access: yesFEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian   +6 more
wiley   +1 more source

The impact of endodontic anatomy on clinical practice: a micro-CT study and tribute to Prof. Francesco Riitano

open access: yesGiornale Italiano di Endodonzia, 2015
Aim: To evaluate the quality of root canal preparation using two different mechanical NiTi systems. Methodology: 40 maxillary and mandibular molars were selected.
Nicola Maria Grande   +4 more
doaj   +1 more source

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