Results 211 to 220 of about 420,905 (352)
Innovative 3D-printed dental teaching model for root canal treatment simulation. [PDF]
Chen SY +6 more
europepmc +1 more source
Targeted Degradation of sGRP78 Alleviates the Immunosuppressive Tumor Microenvironment
Soluble GRP78 (sGRP78) is identified as a novel tumor‐derived soluble factor that induces regulatory T cells (Treg). sGRP78 serves as an excellent serological biomarker for predicting the efficacy of neoadjuvant therapy in breast cancer patients. sGRP78 specifically binds to B cells, inducing the expression of IL‐10 and PD‐L1, thereby promoting Treg ...
Zhenghao Wu +10 more
wiley +1 more source
Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion, followed by delayed invasion with matrix reorganization and proliferation.
Kabilan Sakthivel +8 more
wiley +1 more source
Anxiety among patients with single versus multiple visits for root canal treatment. [PDF]
G S +5 more
europepmc +1 more source
Endodontic Treatment of Primary Mandibular First Molars with Single Root and Single Canal [PDF]
Neslihan Özveren, Şerife ÖZALP
openalex +1 more source
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha +12 more
wiley +1 more source
Dentists’ knowledge of non-surgical root canal treatment, a systematic review
Edmund Monsef +3 more
openalex +1 more source
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source

