Results 231 to 240 of about 420,905 (352)

Programmable Hydrogels: Frontiers in Dynamic Closed‐Loop Systems, Biomimetic Synergy, and Clinical Translation

open access: yesAdvanced Science, EarlyView.
This review summarizes the design principles and key features of programmable hydrogels that respond to multiple stimuli. It then delves into the cutting‐edge mechanisms of self‐executing systems, highlighting their role as the cornerstone of next‐generation programmable hydrogels (NGPHs).
Guangli Xiang   +8 more
wiley   +1 more source

Genetically Engineered Light‐Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen   +11 more
wiley   +1 more source

Interface‐Adaptive Dual‐Color Hydrogel with Self‐Repairing Function and High Adhesion as Flexible Wearable Sensor for Minimally‐Invasive Monitoring Pesticide Residue in Living Crop

open access: yesAdvanced Science, EarlyView.
Dual‐color hydrogel TPE@Mn@ZnS@AG@PVA is prepared using b‐TPE NPs and r‐Mn@ZnS QDs as blue‐channel and red‐channel indicators, exhibits smart interface adaptability, high adhesion, good self‐repairing function, and superior response to thiophannate‐methyl, and thus acts as a flexible wearable sensor for in situ, on‐site and minimally‐destructive ...
Jianling Chen   +8 more
wiley   +1 more source

Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis

open access: yesAdvanced Science, EarlyView.
This study shows that mammary branching morphogenesis is regulated by extracellular matrix (ECM) stress relaxation. Slow stress‐relaxing matrices promote branching through focal adhesion signaling, collagen fiber alignment, and cell contractions, whereas fast stress‐relaxing matrices impair branching and collagen alignment.
Daniella I. Walter   +3 more
wiley   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

open access: yesAdvanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du   +14 more
wiley   +1 more source

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