Results 161 to 170 of about 1,671,483 (282)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Using root cause analysis to improve the quality of loaner instrument receiving in the central sterile supply department: A retrospective study. [PDF]

J Int Med Res
Qin N, Huang H, Chen H, Rao J, Zhou X, Zeng A, Zeng Q.   +6 more
europepmc   +1 more source

Optimizing Sterilization Packaging through Root Cause Analysis: An Exploration into Sealing Defects of Paper-Plastic Pouches. [PDF]

Med Sci Monit, 2023
Jiang S, Yi L, Chen Y, Hu R.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Root Cause Analysis of Omissions and Delays in the Initiation of Neoadjuvant Chemotherapy in Eligible Patients with Breast Cancer in British Columbia, Canada. [PDF]

Curr Oncol
Chan JLH, Lee JJ, Ohm H, Isaac KV, Nichol A.   +4 more
europepmc   +1 more source

Root Cause Analysis of Degradation in Protonic Ceramic Electrochemical Cell with Interfacial Electrical Sensors Using Data-Driven Machine Learning. [PDF]

Adv Sci (Weinh), 2023
Wu W, Wang C, Bian W, Hua B, Gomez JY, Orme CJ, Tang W, Stewart FF, Ding D.   +8 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Insights from a measles outbreak root cause analysis in Ethiopia - 2024. [PDF]

Pan Afr Med J
Alemu MA, Dema ST, Anteneh HA, Guade HT, Gebrekidan AH, Mersha AM, Lakew GA, Tufa YA, Shibeshi EZ, Nibzane GT, Hailemariam FT, Kita YG, Yimam F, Ayana WB, Hailekiros T, Amene K, Atakilti R, Alemu E, Yeshaw O, Malumo S, Kokebe MA, Getaneh MW, Afele MA, Masresha BG.   +23 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Root causes and fields of action to address unplanned hospitalisation in long-term care: a multiple case study with root-cause analysis. [PDF]

BMC Nurs
Pohontsch NJ, Huckle TA, Jarchow AM, Balzer K, Silies KT.   +4 more
europepmc   +1 more source