Results 141 to 150 of about 2,158,107 (298)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Effects of Abscisic Acid Induction on the Underground Weed Inhibition Strategies of Allelopathic and Non-Allelopathic Rice Accessions

Plants
Despite our preliminary research about the inductive effect of exogenous abscisic acid (ABA) on the weed-suppressive activity of rice in a hydroponic system, there is a lack of knowledge regarding the induction mechanism for ABA application to enhance ...
Jiayu Li, Ting Wang, Xinyi Ye, Shuyu Chen, Yanping Wang, Changxun Fang   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Deep root system architecture from a combination of DRO1 and qRL6.1 maintains high photosynthesis during rice grain-filling in paddy fields

Plant Production Science
The source capacity affects grain yields. Many efforts have been made to enhance grain yields by introducing quantitative trait loci (QTLs) responsible for shoot-related traits associated with source capacity. Root-related traits could improve the source
Momoha Iba, Yumiko Arai-Sanoh, Ryokei Tanaka, Yuka Kitomi, Shota Teramoto, Kenji Irie, Yusaku Uga   +6 more
doaj   +1 more source

Unit Root Model Selection [PDF]

Some limit properties for information based model selection criteria are given in the context of unit root evaluation and various assumptions about initial conditions. Allowing for a nonparametric short memory component, standard information criteria are
Peter C.B. Phillips
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Improvement of Transplanting Rice Yield and Nitrogen Use Efficiency by Increasing Planting Density in Northeast China Under the Optimal Nitrogen Split-Fertilizer Applications

Agriculture
There are few studies on how nitrogen (N) fertilizer application rates and transplanting densities impact rice yield, root distribution, and N use efficiency in the cold regions of Northeast China.
Zichen Liu, Wanchun Li, Shujuan Geng, Rui Zhang, Man Dou, Meikang Wu, Liangdong Li, Dongchao Wang, Xiaoshuang Wei, Ping Tian, Meiying Yang, Zhihai Wu, Lei Wu   +12 more
doaj   +1 more source

Limited time series with a unit root [PDF]

This paper develops an asymptotic theory for integrated and near-integrated time series whose range is constrained in some ways. Such a framework arises when integration and cointegration analysis are applied to persistent series which are bounded either
Giuseppe Cavaliere
core   +1 more source

Limiting Distribution of a Root of a Determinantal Equation

The Annals of Mathematical Statistics, 1948
The exact distribution of a root of a determinantal equation when the roots are arranged in a monotonic order was obtained by S. N. Roy [3] in 1943. A different method for deriving the distribution of any one of these roots has been described by the author in [2]. In the present paper the limiting forms of these distributions are obtained.
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source