Results 121 to 130 of about 182,479 (288)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Root traits (biomass, length, root length density, diameter, surface area, volume, tips, forks and crossings) in the Jena-Ecotron experiment

, 2017
This dataset contains root traits (biomass, length, diameter, surface area, tips, forks and crossings) in the Jena-Ecotron Experiment in 2012. This experiment was conducted in the Montpellier European Ecotron (CNRS, France), an advanced controlled ...
Dörte Bachmann (8020184), Alexandra Weigelt (6963755), Gockele, Annette, Marcus Guderle (8016407), Gessler, Arthur, Weigelt, Alexandra, Annette Gockele (683614), Bachmann, Dörte, Arthur Gessler (8015963), Guderle, Marcus, Scherer-Lorenzen, Michael, Michael Scherer-Lorenzen (164624)   +11 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Root hair length and density in loss of function mutants of candidate genes.

, 2015
(A) Root hair density of wild type (Col-0), rlp48–1, aox1d-1, at1g32360–1, cyr1 (all mutants in the Col-0 background). Black bars: with P, grey bars: without P. (B) Root hair length of wild type (Col-0), rlp48–1, aox1d-1, at1g32360–1, cyr1.
Karl Schmid (375809), Markus G. Stetter (703871), Uwe Ludewig (1151)   +2 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The distribution of fine root length density for six artificial afforestation tree species in Loess Plateau of Northwest China

, 2015
Aim of the study: Data about the distribution of fine root length density (FRLD) is important to understand the ecophysiology of vegetation. This is particularly true when models are applied to describe ecohydrology and vegetation function.
Shengqi Jian, Fang, Shumin, Chuanyan Zhao, Shumin Fang, Jian, Shengqi, Kai Yu, Zhao, Chuanyan, Yu, Kai   +7 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Fine-Root Responses of Populus tomentosa Forests to Stand Density

, 2018
Stand density directly affects the distribution of ecological factors such as light, heat, and water in forest communities and changes the diversity and structure of undergrowth species, thereby affecting soil health.
Yatao Yue, Chunyan Wen, Huijuan Bo, Lianjun Song, Lishui Nie   +4 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source